Department of Biochemistry and Molecular Biology, Building 77, Monash University, Wellington Rd., Clayton, Vic 3800, Australia.
FEBS Lett. 2012 Jul 30;586(16):2212-7. doi: 10.1016/j.febslet.2012.06.020. Epub 2012 Jun 21.
Endothelin Converting Enzyme-1 (ECE-1) plays a significant role in the regulation of vascular tone and hence blood pressure. It has also been implicated in the pathogenesis of cardiovascular diseases, female malignancies and Alzheimer's disease. Four different isoforms of ECE-1 exist and have varying degrees of distribution throughout the cell. Production of ET-1 by ECE-1 occurs at the cell surface and the expression and localisation of ECE-1 is the rate limiting step in the production of ET-1. This review looks at the current knowledge on ECE-1 phosphorylation and other stimuli which act induce trafficking of ECE-1 to the cell surface.
内皮素转化酶 1（ECE-1）在调节血管张力和血压方面起着重要作用。它也与心血管疾病、女性恶性肿瘤和阿尔茨海默病的发病机制有关。ECE-1 存在四种不同的同工型，在细胞内的分布程度也不同。ECE-1 在细胞表面产生 ET-1，ECE-1 的表达和定位是 ET-1 产生的限速步骤。本文综述了 ECE-1 磷酸化的最新知识，以及其他刺激因素诱导 ECE-1 向细胞表面转运的情况。
