Department of Laboratory Medicine, Buddhist Tzu Chi General Hospital, Hualien, Taiwan.
Indian Pediatr. 2013 Feb;50(2):209-13. doi: 10.1007/s13312-013-0068-2. Epub 2012 Jun 10.
To study, we examined the effect of Lactobacillus salivarius on the clinical symptoms and medication use among children with established allergic rhinitis (AR).
Double blind, randomized, controlled trial.
Hualien Tzu-Chi General Hospital.
Atopic children with current allergic rhinitis received 4x10(9) colony forming units/g of Lactobacillus salivarius (n=99) or placebo (n=100) daily as a powder mixed with food or water for 12 weeks. The SCORing Allergic rhinitis index (specific symptoms scores [SSS] and symptom medication scores [SMS]), which measures the extent and severity of AR, was assessed in each subject at each of the visits--2 weeks prior to treatment initiation (visit 0), at the beginning of the treatment (visit 1), then at 4 (visit 2), 8 (visit 3) and 12 weeks (visit 4) after starting treatment. The WBC, RBC, platelet and, eosinophil counts as well as the IgE antibody levels of the individuals were evaluated before and after 3 months of treatment.
The major outcome, indicating the efficacy of Lactobacillus salivarius treatment, was the reduction in rhinitis symptoms and drug scores. No significant statistical differences were found between baseline or 12 weeks in the probiotic and placebo groups for any immunological or blood cell variables.
Our study demonstrates that Lactobacillus salivarius treatment reduces rhinitis symptoms and drug usage in children with allergic rhinitis.
研究唾液乳杆菌对已确诊过敏性鼻炎（AR）儿童临床症状和药物使用的影响。
双盲、随机、对照试验。
花莲慈济医院。
患有特应性过敏性鼻炎的儿童每天接受 4x10(9) 个菌落形成单位/g 的唾液乳杆菌（n=99）或安慰剂（n=100），作为粉末与食物或水混合服用，持续 12 周。采用过敏性鼻炎评分（特定症状评分[SSS]和症状药物评分[SMS]）评估每位受试者在每次就诊时的 AR 严重程度和范围，在治疗开始前 2 周（就诊 0）、治疗开始时（就诊 1）、治疗后 4 周（就诊 2）、8 周（就诊 3）和 12 周（就诊 4）进行评估。在治疗 3 个月前后评估个体的白细胞计数（WBC）、红细胞计数（RBC）、血小板计数和嗜酸性粒细胞计数以及 IgE 抗体水平。
主要结果表明唾液乳杆菌治疗的疗效，即减轻鼻炎症状和药物评分。在益生菌组和安慰剂组中，基线或 12 周时，任何免疫或血细胞变量均无显著统计学差异。
我们的研究表明，唾液乳杆菌治疗可减轻过敏性鼻炎儿童的鼻炎症状和药物使用。
