Wang Ming Fuu, Lin Hsiao Chuan, Wang Ying Yu, Hsu Ching Hsiang
Division of Allergy, Immunology, and Rheumatology, Department of Pediatrics, China Medical University Hospital, Taichung, Taiwan, ROC.
Pediatr Allergy Immunol. 2004 Apr;15(2):152-8. doi: 10.1111/j.1399-3038.2004.00156.x.
Probiotics are perceived to exert beneficial effects in the prevention and treatment of allergic diseases via modifying the gut ecosystem. The aim of this study was to assess whether ingestion of fermented milk containing Lactobacillus paracasei-33 (LP-33), a strain newly isolated from the human intestinal tract, can improve the quality of life of patients with perennial allergic rhinitis. In a randomized, double-blind, placebo-controlled trial, we gave patients fermented milk with (n = 60) or without (n = 20) the addition of LP-33 (2 x 10(9) colony-forming units per bottle) for 30 days. A modified questionnaire concerning pediatric rhinoconjunctivitis quality of life was administered to all subjects or their parents at each clinical visit. Scores for the overall quality of life significantly decreased in the LP-33 group as compared with the placebo group, in both frequency (-16.02 +/- 2.14 vs. -7.27 +/- 3.55, respectively; p = 0.037) and level of bother (-16.35 +/- 2.33 vs. -6.20 +/- 3.13, respectively; p = 0.022) after the 30-day treatment. Subjects reported no severe adverse effects such as fever, abdominal pain, or diarrhea. The results suggest that ingestion of LP-33-fortified fermented milk for 30 days can effectively and safely improve the quality of life of patients with allergic rhinitis, and may serve as an alternative treatment for allergic rhinitis.
益生菌被认为可通过调节肠道生态系统对过敏性疾病的预防和治疗发挥有益作用。本研究的目的是评估摄入含有副干酪乳杆菌-33（LP-33，一种新从人类肠道分离出的菌株）的发酵乳是否能改善常年性变应性鼻炎患者的生活质量。在一项随机、双盲、安慰剂对照试验中，我们给予患者添加（n = 60）或未添加（n = 20）LP-33（每瓶2×10⁹ 菌落形成单位）的发酵乳，持续30天。在每次临床就诊时，向所有受试者或其父母发放一份关于儿童鼻结膜炎生活质量的改良问卷。与安慰剂组相比，LP-33组在30天治疗后的生活质量总分在频率（分别为-16.02±2.14对-7.27±3.55；p = 0.037）和困扰程度（分别为-16.35±2.33对-6.20±3.13；p = 0.022）方面均显著下降。受试者未报告发热、腹痛或腹泻等严重不良反应。结果表明，摄入含LP-33的强化发酵乳30天可有效且安全地改善变应性鼻炎患者的生活质量，并可能作为变应性鼻炎的一种替代治疗方法。
