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Use of pharmacokinetic data below lower limit of quantitation values.

作者信息

Jusko William J

机构信息

Department of Pharmaceutical Sciences School of Pharmacy & Pharmaceutical Sciences, University at Buffalo, Buffalo, New York 14214, USA.

出版信息

Pharm Res. 2012 Sep;29(9):2628-31. doi: 10.1007/s11095-012-0805-6. Epub 2012 Jun 23.

DOI:10.1007/s11095-012-0805-6
PMID:22729370
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3422429/
Abstract
摘要

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本文引用的文献

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Handling data below the limit of quantification in mixed effect models.在混合效应模型中处理低于定量限的数据。
AAPS J. 2009 Jun;11(2):371-80. doi: 10.1208/s12248-009-9112-5. Epub 2009 May 19.
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Likelihood based approaches to handling data below the quantification limit using NONMEM VI.使用NONMEM VI基于似然法处理低于定量限的数据。
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Impact of censoring data below an arbitrary quantification limit on structural model misspecification.将低于任意定量限的数据进行删失对结构模型误设的影响。
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Quantitative bioanalytical methods validation and implementation: best practices for chromatographic and ligand binding assays.定量生物分析方法的验证与实施：色谱及配体结合分析的最佳实践
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Ultra-sensitive quantification of corticosteroids in plasma samples using selective solid-phase extraction and reversed-phase capillary high-performance liquid chromatography/tandem mass spectrometry.使用选择性固相萃取和反相毛细管高效液相色谱/串联质谱法对血浆样品中的皮质类固醇进行超灵敏定量分析。
Anal Chem. 2007 May 15;79(10):3786-93. doi: 10.1021/ac062184r. Epub 2007 Apr 6.
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Single-dose pharmacokinetics and pharmacodynamics of RWJ 67657, a specific p38 mitogen-activated protein kinase inhibitor: a first-in-human study.特异性p38丝裂原活化蛋白激酶抑制剂RWJ 67657的单剂量药代动力学和药效学：一项人体首次研究。
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Diversity of mechanism-based pharmacodynamic models.基于机制的药效学模型的多样性。
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Impact of omission or replacement of data below the limit of quantification on parameter estimates in a two-compartment model.两室模型中低于定量限的数据遗漏或替换对参数估计的影响。
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Ways to fit a PK model with some data below the quantification limit.用一些低于定量限的数据拟合药代动力学（PK）模型的方法。
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Modeling of dose-response-time data: four examples of estimating the turnover parameters and generating kinetic functions from response profiles.剂量-反应-时间数据建模：从反应曲线估计周转参数并生成动力学函数的四个示例。
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