Use of pharmacokinetic data below lower limit of quantitation values.
作者信息
Jusko William J
机构信息
Department of Pharmaceutical Sciences School of Pharmacy & Pharmaceutical Sciences, University at Buffalo, Buffalo, New York 14214, USA.
出版信息
Pharm Res. 2012 Sep;29(9):2628-31. doi: 10.1007/s11095-012-0805-6. Epub 2012 Jun 23.
Abstract
摘要
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本文引用的文献
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Likelihood based approaches to handling data below the quantification limit using NONMEM VI.使用NONMEM VI基于似然法处理低于定量限的数据。
J Pharmacokinet Pharmacodyn. 2008 Aug;35(4):401-21. doi: 10.1007/s10928-008-9094-4. Epub 2008 Aug 7.
3
Impact of censoring data below an arbitrary quantification limit on structural model misspecification.将低于任意定量限的数据进行删失对结构模型误设的影响。
J Pharmacokinet Pharmacodyn. 2008 Feb;35(1):101-16. doi: 10.1007/s10928-007-9078-9. Epub 2007 Oct 26.
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Quantitative bioanalytical methods validation and implementation: best practices for chromatographic and ligand binding assays.定量生物分析方法的验证与实施：色谱及配体结合分析的最佳实践
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Anal Chem. 2007 May 15;79(10):3786-93. doi: 10.1021/ac062184r. Epub 2007 Apr 6.
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Single-dose pharmacokinetics and pharmacodynamics of RWJ 67657, a specific p38 mitogen-activated protein kinase inhibitor: a first-in-human study.特异性p38丝裂原活化蛋白激酶抑制剂RWJ 67657的单剂量药代动力学和药效学：一项人体首次研究。
J Clin Pharmacol. 2003 Apr;43(4):406-13. doi: 10.1177/0091270002250615.
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Diversity of mechanism-based pharmacodynamic models.基于机制的药效学模型的多样性。
Drug Metab Dispos. 2003 May;31(5):510-8. doi: 10.1124/dmd.31.5.510.
8
Impact of omission or replacement of data below the limit of quantification on parameter estimates in a two-compartment model.两室模型中低于定量限的数据遗漏或替换对参数估计的影响。
Pharm Res. 2002 Dec;19(12):1835-40. doi: 10.1023/a:1021441407898.
9
Ways to fit a PK model with some data below the quantification limit.用一些低于定量限的数据拟合药代动力学（PK）模型的方法。
J Pharmacokinet Pharmacodyn. 2001 Oct;28(5):481-504. doi: 10.1023/a:1012299115260.
10
Modeling of dose-response-time data: four examples of estimating the turnover parameters and generating kinetic functions from response profiles.剂量-反应-时间数据建模：从反应曲线估计周转参数并生成动力学函数的四个示例。
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