Department of Cardiology, Aviation General Hospital, An Ding Men Wai Bei Yuan Road 3, Beijing 100012, China.
Cell Biochem Biophys. 2012 Nov;64(2):161-8. doi: 10.1007/s12013-012-9385-7.
The objective of the study was to evaluate the effect of ibutilide on canine cardiac sinoatrial and atrioventricular nodes (AVNs). For this purpose, 18 mongrel dogs were injected intravenously with ibutilide and the changes in heart rate, sinus node recovery time, and AVN were measured. Our data show that ibutilide administration caused significant suppression of the sinus atrial node, the peak response time was 20-30 min, and the heart rate was restored to pre-drug administration level. After receiving ibutilide, 1 animal had a 5 s sinus pause, and after 5 min of ibutilide administration, 1 dog showed 2:1 atrioventricular conduction. Therefore, it was concluded that ibutilide had a suppressive effect on the sinoatrial node and AVN.
本研究旨在评估伊布利特对犬心窦房结和房室结（AVN）的影响。为此，将 18 只杂种犬静脉注射伊布利特，并测量心率、窦房结恢复时间和 AVN 的变化。我们的数据显示，伊布利特给药显著抑制窦房结，其峰值反应时间为 20-30 分钟，心率恢复到给药前水平。给予伊布利特后，1 只动物出现 5 秒窦性停搏，给予伊布利特 5 分钟后，1 只狗出现 2:1 房室传导。因此，结论认为伊布利特对窦房结和房室结有抑制作用。
