Tantam D, Evered C, Hersov L
University Hospital of South Manchester, UK.
J Am Acad Child Adolesc Psychiatry. 1990 Nov;29(6):892-6. doi: 10.1097/00004583-199011000-00008.
Two autistic girls and one autistic man in whom Asperger's syndrome coexists with lifelong ligamentous laxity and muscular incoordination are described. Two had cranial circumferences at or above the 90th percentile as children, two have complex partial epilepsy, one has a colloid cyst of the third ventricle, and one had evidence of Sotos syndrome. Echocardiography was performed in the two girls and both had evidence of increased aortic compliance. It is suggested that all three suffer from a Marfan-like disorder of connective tissue and, more speculatively, that this has led to anomalous development of midline brain structures with consequent social handicaps characteristic of Asperger's syndrome.
本文描述了两名患有阿斯伯格综合征且终生伴有韧带松弛和肌肉不协调的自闭症女孩以及一名自闭症男性。其中两名儿童的头围在第90百分位或以上，两名患有复杂部分性癫痫，一名患有第三脑室胶样囊肿，一名有索托斯综合征的迹象。对两名女孩进行了超声心动图检查，两人均有主动脉顺应性增加的证据。提示这三人都患有类马凡氏结缔组织疾病，更具推测性的是，这导致了中线脑结构的异常发育，从而出现了阿斯伯格综合征特有的社交障碍。
