BMI1 和 p16 在喉鳞状细胞癌中的表达。
Expression of BMI1 and p16 in laryngeal squamous cell carcinoma.
机构信息
Department of Otolaryngology-Head and Neck Surgery, University Magna Graecia of Catanzaro, Italy.
出版信息
Head Neck. 2013 Jun;35(6):847-51. doi: 10.1002/hed.23042. Epub 2012 Jun 22.
BACKGROUND
The clinical evolution of laryngeal squamous cell carcinoma (SCC) is undetectable with the current staging criteria. To more completely understand the biology of laryngeal SCC, we assessed the expression of the proteins B-cell-specific Moloney murine leukemia virus integration site 1 (BMI1) and p16.
METHODS
We assessed immunohistochemically the expression of BMI1 and p16 in 25 laryngeal SCCs at different stages.
RESULTS
High BMI1 expression was detected in 11.7% of glottic tumors and in 50% of supraglottic tumors. No significant differences were observed in the patients' clinical data after they were stratified by the tumor expression of p16. The expression of nuclear BMI1 in the absence of p16 immunoreactivity correlated significantly with the pN status of the primary tumors.
CONCLUSION
Nuclear BMI1 expression in the absence of p16 expression seems to characterize a subset of patients with a high risk of developing lymph node metastasis.
背景
目前的分期标准无法检测喉鳞状细胞癌（SCC）的临床演变。为了更全面地了解喉 SCC 的生物学特性，我们评估了 B 细胞特异性 Moloney 鼠白血病病毒整合位点 1（BMI1）和 p16 蛋白的表达。
方法
我们采用免疫组织化学方法检测了 25 例不同分期的喉 SCC 中 BMI1 和 p16 的表达。
结果
在声门型肿瘤中，BMI1 高表达率为 11.7%，在声门上型肿瘤中，BMI1 高表达率为 50%。对 p16 免疫反应性肿瘤进行分层后，患者的临床数据无显著差异。在 p16 无免疫反应性的情况下，核 BMI1 的表达与原发性肿瘤的 pN 状态显著相关。
结论
在缺乏 p16 表达的情况下，核 BMI1 的表达似乎可以作为一组具有高发生淋巴结转移风险的患者的特征。
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