Department of Child and Adolescent Psychiatry, Hospital Sant Joan de Déu , CIBERSAM, Esplugues del Llobregat, Barcelona, Spain.
Int J Psychiatry Clin Pract. 2013 Feb;17(1):2-9. doi: 10.3109/13651501.2012.687452. Epub 2012 Jun 26.
To assess risk factors for relapse in patients with schizophrenia attended in daily practice.
Patients with schizophrenia admitted consecutively to short-stay/acute-care psychiatric units over a 6-month period were eligible. Variables statistically significant in the univariate logistic regression analysis were then subjected to multivariate analysis.
The study population included 1646 patients (67.6% men). In the univariate analysis, low family support, duration of illness > 5 years, number of previous hospitalizations, cocaine and cannabis consumption, and number of different antipsychotic drug classes were risk factors for relapse. In the multivariate analysis, number of previous hospitalizations (odds ratio [OR] 1.29, 95% confidence interval [CI] 1.21-1.36) and number of different antipsychotics previously used (OR = 1.13, 95% CI 1.03-1.24) were significant predictors of relapse. The absence of cannabis consumption was a protective factor (OR = 0.72, 95% CI 0.58-0.89). Neither adherence to treatment in the previous 3 years nor type of antipsychotic regimen was significantly associated with relapse.
Number of previous hospitalizations and number of different types of antipsychotic drugs were associated with relapse. Absence of cannabis consumption was a protective factor.
评估在日常实践中接受治疗的精神分裂症患者复发的危险因素。
连续 6 个月内入住短期/急性精神病病房的精神分裂症患者符合入选条件。对单变量逻辑回归分析中具有统计学意义的变量进行多变量分析。
研究人群包括 1646 名患者（67.6%为男性）。单变量分析中，家庭支持度低、病程 > 5 年、既往住院次数、可卡因和大麻使用以及不同抗精神病药物种类数量是复发的危险因素。多变量分析中，既往住院次数（比值比 [OR] 1.29，95%置信区间 [CI] 1.21-1.36）和既往使用的不同抗精神病药物种类数量（OR = 1.13，95% CI 1.03-1.24）是复发的显著预测因素。无大麻使用史是保护因素（OR = 0.72，95% CI 0.58-0.89）。既往 3 年内治疗依从性和抗精神病药物方案类型与复发均无显著相关性。
既往住院次数和不同类型抗精神病药物的使用数量与复发相关。无大麻使用史是保护因素。
