[The effect of sugars on the activity of sorbitol dehydrogenase from the cytoplasm of bovine liver cells].

The effect of sugar and its phosphate derivatives on sorbitoldehydrogenase from bovine liver has been studied. The presence of 100 mM glucose, mannose, and arabinose did not influence that activity of the studied reaction, whereas fructose, sorbose, and xylose, inhibit the reaction by 20-25%. This can be explained in terms of inhibition by the final reaction products. Inhibition by glucose-6-phosphate (24%), glucose-1-phosphate (21%), and fructose-6-phosphate (42%) is of particular interest since these compounds may play a regulatory role.