Department of Psychiatry, Brown Medical School, Providence, RI, USA.
Clin Neuropsychol. 2012;26(6):879-93. doi: 10.1080/13854046.2012.699102. Epub 2012 Jun 25.
Alcohol-related dementia (ARD) is a controversial concept, and the prevailing view of neuropsychologists regarding this disorder is unknown. The purpose of this study was to gain an understanding of neuropsychologists' beliefs and practices regarding ARD. A total of 140 board-certified neuropsychologists completed an anonymous online survey about alcohol and dementia. Almost all respondents (93%) reported alcohol has direct neurotoxic effects, but most were unsure whether moderate alcohol use can be neuroprotective. The presence and course of cognitive deficits as well as functional impairments were rated as the most important factors to consider when making this diagnosis, and declines in memory, executive functions, and processing speed were most frequently observed cognitive changes. Neuropsychologists were mixed in their opinions about cognitive prognosis, with half the sample endorsing stability of cognitive deficits and about one-third of the group indicating gradual improvement. Although laboratory workup was not a major diagnostic consideration, 68% of respondents recommended treatment with vitamins and nutritional supplements. Findings are consistent with the research literature and suggest that while neuropsychologists generally believe alcohol can have direct neurotoxic effects, they vary in their beliefs about diagnosis, treatment, and prognosis. Future research should focus on providing diagnostic and treatment guidelines for ARD.
酒精相关痴呆症(ARD)是一个有争议的概念,神经心理学家对这种疾病的普遍看法尚不清楚。本研究旨在了解神经心理学家对 ARD 的信念和实践。共有 140 名经过董事会认证的神经心理学家完成了一项关于酒精和痴呆的匿名在线调查。几乎所有的受访者(93%)都报告说酒精具有直接的神经毒性作用,但大多数人不确定适量饮酒是否具有神经保护作用。认知缺陷和功能障碍的存在和病程被评为做出这一诊断时最需要考虑的因素,记忆、执行功能和处理速度的下降是最常见的认知变化。神经心理学家对认知预后的看法存在分歧,一半的样本支持认知缺陷的稳定性,大约三分之一的小组表示认知缺陷逐渐改善。尽管实验室检查不是主要的诊断考虑因素,但 68%的受访者建议使用维生素和营养补充剂进行治疗。研究结果与研究文献一致,表明尽管神经心理学家普遍认为酒精具有直接的神经毒性作用,但他们对诊断、治疗和预后的看法存在差异。未来的研究应集中在为 ARD 提供诊断和治疗指南上。