Sallard Etienne, Barral Jérôme, Duffau Hugues, Bonnetblanc François
Unité de Formation et de Recherche en Sciences et Techniques des Activités Physiques et Sportives, Université de Bourgogne, F-21078 Dijon, France.
Brain Inj. 2012;26(13-14):1750-5. doi: 10.3109/02699052.2012.698792. Epub 2012 Jun 25.
Awake surgeries of slow-growing tumours invading the brain and guided by direct electrical stimulation induce major brain reorganizations accompanied with slight impairments post-operatively. In most cases, these deficits are so slight after a few days that they are often not detectable on classical neuropsychological evaluations. Consequently, this study investigated whether simple visuo-manual reaction time paradigms would sign some level of functional asymmetries between both hemispheres. Importantly, the visual stimulus was located in the saggital plane in order to limit attentional biases and to focus mainly on the inter-hemispheric asymmetry.
Three patients (aged 41, 59 and 59 years) after resections in parietal regions and a control group (age = 44, SD = 6.9) were compared during simple uni- and bimanual reaction times (RTs).
Longer RTs were observed for the contralesional compared to the ipsilesional hand in the unimanual condition. This asymmetry was reversed for the bimanual condition despite longer RTs.
Reaction time paradigms are useful in these patients to monitor more precisely their functional deficits, especially their level of functional asymmetry, and to understand brain (re)organization following slow-growing lesions.
由直接电刺激引导的、针对侵犯大脑的生长缓慢肿瘤的清醒手术会引发大脑的重大重组，并伴有术后的轻微损伤。在大多数情况下，这些缺陷在几天后非常轻微，以至于在经典神经心理学评估中往往无法检测到。因此，本研究调查了简单的视觉手动反应时范式是否会显示出两个半球之间某种程度的功能不对称。重要的是，视觉刺激位于矢状面，以限制注意力偏差，并主要关注半球间不对称。
比较了3例（年龄分别为41岁、59岁和59岁）顶叶区域切除术后的患者和一个对照组（年龄=44岁，标准差=6.9）在简单单手和双手反应时（RT）方面的情况。
在单手条件下，与同侧手相比，对侧手的反应时更长。尽管双手条件下反应时更长，但这种不对称性发生了逆转。
反应时范式有助于更精确地监测这些患者的功能缺陷，尤其是他们的功能不对称水平，并了解生长缓慢病变后的大脑（重新）组织情况。
