Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Am J Rhinol Allergy. 2012 Jul-Aug;26(4):315-20. doi: 10.2500/ajra.2012.26.3790. Epub 2012 Jun 21.
There have been few longitudinal investigations of allergic rhinitis (AR) in Chinese children. We previously conducted an investigation of the prevalence of AR in 3- to 6-year old children for the year of 2005-2006. The aim of this study was to observe the natural course of AR in children in the previously investigated population during a cohort study for 5 years.
A total of 1211 children in the previously investigated population were included in this study. Telephone interviews were conducted three times during the 1st, 3rd, and 5th year from the previous study.(14) Questions including duration, severity of nasal symptoms, asthma, and related problems of allergy were examined. Skin-prick tests (SPTs) were performed again on those children who had done SPTs in the previous study(14) after the last follow-up (i.e., after 5 years).
Of the 1211 children, 870 (71.8%) completed the 5-year observation period. In the 5th year, the prevalence of positive nasal symptoms was 29.4% (256 of the 870 children), including 64/70 (91.4%) of those who were formerly symptom positive and SPT(+), 45/104 (43.3%) of those who were formerly symptom positive and SPT(-), 40/66 (60.6%) of those who were formerly symptom positive with SPTs not performed (SPTs[x]), and 107/630 (17.0%) of those who were formerly symptom negative. SPT results showed that 96.1% (73/76) of previous SPT(+) children remained SPT(+); only 3.9% (6/154) became SPT(+) in previous SPT(-) children.
We concluded that the natural course of AR (symptom positive and SPT(+)) and non-AR (symptom positive and SPT(-)) children were quite different.
在中国儿童中，仅有少数过敏性鼻炎（AR）的纵向研究。我们之前进行了一项针对 2005-2006 年 3-6 岁儿童 AR 患病率的调查。本研究的目的是在之前调查人群中进行为期 5 年的队列研究，观察 AR 患儿的自然病程。
共有 1211 名在之前研究中调查的儿童纳入本研究。在之前研究的第 1、3 和 5 年期间进行了 3 次电话访谈。（14）检查了包括鼻症状持续时间、严重程度、哮喘和过敏相关问题的问题。对那些之前研究中进行过 SPT 的儿童（14）在最后一次随访（即 5 年后）再次进行皮肤点刺试验（SPT）。
在 1211 名儿童中，有 870 名（71.8%）完成了 5 年观察期。第 5 年，阳性鼻部症状的患病率为 29.4%（870 名儿童中有 256 名），其中 64/70（91.4%）为以前症状阳性且 SPT（+），45/104（43.3%）为以前症状阳性且 SPT（-），40/66（60.6%）为以前症状阳性且未进行 SPT（SPTs[x]），107/630（17.0%）为以前症状阴性。SPT 结果显示，96.1%（73/76）以前 SPT（+）的儿童仍为 SPT（+）；仅 3.9%（6/154）以前 SPT（-）的儿童变为 SPT（+）。
我们得出结论，AR（症状阳性和 SPT（+））和非 AR（症状阳性和 SPT（-））儿童的自然病程差异很大。
