Division of Plastic Surgery, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.
Clin Plast Surg. 2012 Jul;39(3):239-48. doi: 10.1016/j.cps.2012.04.003. Epub 2012 May 23.
Cutaneous wound healing is a dynamic process with the ultimate goal of restoring skin integrity. On injury to the skin, inflammatory cells, endothelial cells, fibroblasts, and keratinocytes undergo changes in gene expression and phenotype, leading to cell proliferation, migration, and differentiation. Cytokines and growth factors play an essential role in initiating and directing the phases of wound healing. These signaling peptides are produced by a variety of cells and lead to a concerted effort to restore the skin barrier function.
皮肤创伤愈合是一个动态的过程，其最终目标是恢复皮肤的完整性。当皮肤受到损伤时，炎性细胞、内皮细胞、成纤维细胞和角质形成细胞的基因表达和表型发生变化，导致细胞增殖、迁移和分化。细胞因子和生长因子在启动和指导创伤愈合的各个阶段中起着至关重要的作用。这些信号肽由多种细胞产生，共同努力恢复皮肤屏障功能。
