Shimizu C, Inoue M, Ogawa H, Ueda G, Tanizawa O
Department of Obstetrics and Gynecology, Osaka University Medical School.
Nihon Sanka Fujinka Gakkai Zasshi. 1990 Nov;42(11):1537-42.
In order to estimate the clinical significance of sialyl Tn (STN) antigen, the antigen was measured with an "STN" Otsuka Kit in sera from patients with various gynecologic tumors and healthy women. The antigen in ovarian fluid was also determined. Furthermore, the amount of serum STN antigen was serially checked in the patients with increased serum STN to evaluate the correlation between serum STN and the response to treatment. Results obtained were as follows. 1) Among the patients with uterine myoma, uterine malignancies and benign ovarian tumors, the incidence of increased serum STN antigen was low. 2) Among the patients with ovarian malignancies, serum STN antigen was significantly increased in the following order: Clinical stage I (18%) stage II (22%) stage III (68%). 3) The highest STN value was observed in the cyst fluid from ovarian malignancies. 4) The serum STN concentration was correlated with the effect of treatment. Interestingly, the increase in serum STN preceded the clinical detection of recurrence in one case. Thus STN appears to be a useful marker for monitoring ovarian malignancies.
为评估唾液酸化Tn（STN）抗原的临床意义，使用大冢“STN”试剂盒检测了各种妇科肿瘤患者及健康女性血清中的该抗原。同时也测定了卵巢液中的抗原。此外，对血清STN升高的患者连续检测血清STN抗原量，以评估血清STN与治疗反应之间的相关性。结果如下：1）子宫肌瘤、子宫恶性肿瘤和卵巢良性肿瘤患者中，血清STN抗原升高的发生率较低。2）在卵巢恶性肿瘤患者中，血清STN抗原显著升高，顺序如下：临床I期（18%）、II期（22%）、III期（68%）。3）在卵巢恶性肿瘤的囊液中观察到最高的STN值。4）血清STN浓度与治疗效果相关。有趣的是，有1例血清STN升高先于临床复发检测。因此，STN似乎是监测卵巢恶性肿瘤的有用标志物。
