Noda K, Shiota M, Tanizawa O, Inoue M, Tenjin Y, Sugishita T, Yakushiji M, Miyoshi T, Nozawa S, Sakuma T
Kinki University School of Medicine, Japan.
Gan To Kagaku Ryoho. 1991 Jul;18(8):1287-96.
Serum sialyl Tn antigen was assayed in gynecological cancer and benign patients by means of "STN OTSUKA" kits. Fifty-eight of 140 (41.1%) ovarian cancer patients showed a significant elevation of sialyl Tn antigen in serum above the cut-off level of 45 unit/ml (mean +2SD) determined from normal controls. There was no feature of positive frequency in tissue type, including serious carcinoma (47.6%), mucinous carcinoma (45.5%), clear cell carcinoma (30.4%) and endometrioid carcinoma (55.6%), but the positive frequency of mucinous carcinoma (36.8%) was higher than that of serous carcinoma (11.1%) in stage I. Compared with other markers, sialyl Tn antigen showed a very much lower false-positive rate (3.6%) in benign gynecological diseases. In the diagnosis of ovarian cancers, the combination assay of sialyl Tn antigen and CA 125 increased diagnostic efficiency compared with any other combination assays. Therefore, sialyl Tn antigen will be a useful tumor marker for ovarian cancers.
采用“STN大冢”试剂盒对妇科癌症患者和良性疾病患者的血清唾液酸化Tn抗原进行检测。140例卵巢癌患者中有58例（41.1%）血清唾液酸化Tn抗原显著升高，高于根据正常对照确定的45单位/毫升（均值+2标准差）的临界值。在组织类型方面，包括浆液性癌（47.6%）、黏液性癌（45.5%）、透明细胞癌（30.4%）和子宫内膜样癌（55.6%），均无阳性频率特征，但在I期，黏液性癌的阳性频率（36.8%）高于浆液性癌（11.1%）。与其他标志物相比，唾液酸化Tn抗原在良性妇科疾病中的假阳性率非常低（3.6%）。在卵巢癌诊断中，与其他任何联合检测方法相比，则唾液酸化Tn抗原与CA 125的联合检测提高了诊断效率。因此，唾液酸化Tn抗原将是一种用于卵巢癌的有用肿瘤标志物。
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