Chemical Engineering Department and Bioengineering Division, Centre for Bioengineering and Biyomedtek, Hacettepe University, Beytepe, Ankara, Turkey.
J Tissue Eng Regen Med. 2013 Jul;7(7):584-8. doi: 10.1002/term.1464. Epub 2012 Jun 26.
Gelatin-based cryogels were prepared by using a novel crosslinker, oxidized dextran, which was synthesized and used in the study. The cryogels were also loaded with freshly formed hydroxyapatite (HA) particles. These cryogels are opaque, spongy and highly elastic and have a pore structure with large interconnected pores. They swell about 500% in aqueous media and within a few minutes reach their final swollen forms. The elastic moduli of HA-containing cryogels were 18.5 ± 3.0 kPa, which is suitable for non-load-bearing bone tissue-engineering (TE) applications, especially for the craniofacial area.
明胶基冷冻凝胶是通过使用一种新型交联剂氧化葡聚糖制备的，该交联剂是在本研究中合成并使用的。冷冻凝胶还负载了新形成的羟基磷灰石（HA）颗粒。这些冷冻凝胶是不透明的、海绵状的、高弹性的，具有大的互连孔的孔结构。它们在水介质中溶胀约 500%，并在几分钟内达到最终的溶胀形式。含 HA 的冷冻凝胶的弹性模量为 18.5 ± 3.0 kPa，适用于非承重骨组织工程（TE）应用，特别是在颅面区域。
