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全膝关节置换与单髁膝关节置换后患者报告结局指标的比较。

Comparison of patient-reported outcome measures following total and unicondylar knee replacement.

作者信息

Baker P N, Petheram T, Jameson S S, Avery P J, Reed M R, Gregg P J, Deehan D J

机构信息

Institute of Cellular Medicine, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, UK.

出版信息

J Bone Joint Surg Br. 2012 Jul;94(7):919-27. doi: 10.1302/0301-620X.94B7.28436.

DOI:10.1302/0301-620X.94B7.28436
PMID:22733946
Abstract

Following arthroplasty of the knee, the patient's perception of improvement in symptoms is fundamental to the assessment of outcome. Better clinical outcome may offset the inferior survival observed for some types of implant. By examining linked National Joint Registry (NJR) and patient-reported outcome measures (PROMs) data, we aimed to compare PROMs collected at a minimum of six months post-operatively for total (TKR: n = 23,393) and unicondylar knee replacements (UKR: n = 505). Improvements in knee-specific (Oxford knee score, OKS) and generic (EuroQol, EQ-5D) scores were compared and adjusted for case-mix differences using multiple regression. Whereas the improvements in the OKS and EQ-5D were significantly greater for TKR than for UKR, once adjustments were made for case-mix differences and pre-operative score, the improvements in the two scores were not significantly different. The adjusted mean differences in the improvement of OKS and EQ-5D were 0.0 (95% confidence interval (CI) -0.9 to 0.9; p = 0.96) and 0.009 (95% CI -0.034 to 0.015; p = 0.37), respectively. We found no difference in the improvement of either knee-specific or general health outcomes between TKR and UKR in a large cohort of registry patients. With concerns about significantly higher revision rates for UKR observed in worldwide registries, we question the widespread use of an arthroplasty that does not confer a significant benefit in clinical outcome.

摘要

膝关节置换术后,患者对症状改善的感知对于评估治疗效果至关重要。更好的临床结果可能会抵消某些类型植入物观察到的较差生存率。通过检查国家关节注册中心(NJR)与患者报告结局测量(PROMs)的关联数据,我们旨在比较全膝关节置换术(TKR:n = 23,393)和单髁膝关节置换术(UKR:n = 505)术后至少六个月收集的PROMs。比较膝关节特异性(牛津膝关节评分,OKS)和通用(欧洲五维度健康量表,EQ-5D)评分的改善情况,并使用多元回归对病例组合差异进行调整。虽然TKR的OKS和EQ-5D改善程度明显大于UKR,但在对病例组合差异和术前评分进行调整后,这两个评分的改善情况没有显著差异。OKS和EQ-5D改善的调整后平均差异分别为0.0(95%置信区间(CI)-0.9至0.9;p = 0.96)和0.009(95%CI -0.034至0.015;p = 0.37)。我们发现,在大量注册患者队列中,TKR和UKR在膝关节特异性或总体健康结局改善方面没有差异。鉴于全球注册中心观察到UKR的翻修率显著更高,我们质疑一种在临床结果上没有显著益处的关节置换术的广泛应用。

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