[乙肝表面抗原阳性母亲所生新生儿的乙肝血清标志物及乙肝病毒DNA检测结果分析]

[Analysis of the test results of HBV serum markers and HBV DNA of the neonates born to HBsAg-positive mothers].

作者信息

Wang Miao-Chan, Xu Ai-Fang, Zhang Yong-Le, Xu Dong-Ming

机构信息

Sixth People's Hospital of Hangzhou 310014, China.

出版信息

Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2011 Dec;25(6):445-7.

PMID:22734231

Abstract

OBJECTIVE

To observe the HBV serum markers and HBV DNA expressions of the neonates born to the HBsAg-positive mothers.

METHODS

By detecting serum immunity markers of hepatitis B virus (5 items) and serum HBV DNA of 283 neonates (a pair of twins) born to 282 HBsAg-positive mothers.

RESULTS

12 patterns emerge from the study of the hepatitis B serum markers of 283 neonates. Topping the list is the combination of HBeAg and anti-HBc positive accounting for 48.41% (137/283), followed by the combination of anti-HBe and anti-HBc positive accounting for 22.26% (62/283). The third highest combination is that of HBsAg, HBeAg and anti-HBc positive accounting for 12.37% (35/283). There are five combinations accounting for 16.61% (47/283), each with HBsAg-positive. No case is found of the five items all negative or only HBsAb positive. Five cases are detected of serum HBV DNA > or = 1 x 103 IU/ml accounting for 1.77%.

CONCLUSIONS

Neonates born to HBsAg-positive mothers display complex patterns of serum hepatitis B markers, the dominant pattern being the combination of HBeAg and anti-HBc positive. Cases of serum HBV DNA > or = 1 x 10(3) IU/ml are rare.

摘要

目的

观察HBsAg阳性母亲所生新生儿的乙肝血清学标志物及HBV DNA表达情况。

方法

对282例HBsAg阳性母亲所生的283例新生儿（其中一对双胞胎）检测血清乙肝病毒免疫标志物（5项）及血清HBV DNA。

结果

对283例新生儿的乙肝血清学标志物研究出现12种模式。排在首位的是HBeAg和抗-HBc阳性组合，占48.41%（137/283），其次是抗-HBe和抗-HBc阳性组合，占22.26%（62/283）。排在第三位的是HBsAg、HBeAg和抗-HBc阳性组合，占12.37%（35/283）。有5种组合占16.61%（47/283），均为HBsAg阳性。未发现5项全阴性或仅HBsAb阳性的情况。检测到5例血清HBV DNA≥1×10³IU/ml，占1.77%。