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Inhibition of [3H]glutamate release by Zn2+ in rat hippocampal slices.

作者信息

Kihara T, Baba A, Koyama Y, Ishihara T, Iwata H

机构信息

Laboratory of Molecular pharmacology, Suntory Institute for Biomedical Research, Osaka Japan.

出版信息

J Pharmacobiodyn. 1990 May;13(5):321-6. doi: 10.1248/bpb1978.13.321.

DOI:10.1248/bpb1978.13.321
PMID:2273448
Abstract

Zn2+ at the concentration of 10 microM inhibited the depolarization-induced [3H]glutamate release from the preloaded rat hippocampal slices both in the presence and absence of Ca2+ without affecting [3H]GABA and [3H]ACh release. Of divalent cations tested, Zn2+ and Fe2+ had an inhibitory effect on the release of glutamate.

摘要

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