[¹³C标记核磁共振（NMR）示踪技术在临床化学中的应用。苯甲酸向马尿酸的代谢率]
[Application of 13C label-nuclear magnetic resonance (NMR) tracer techniques to clinical chemistry. Metabolic rate of benzoic acid to hippuric acid].
作者信息
Baba S, Akira K, Sakuma C
机构信息
Tokyo College of Pharmacy, Japan.
出版信息
Yakugaku Zasshi. 1990 Aug;110(8):586-90. doi: 10.1248/yakushi1947.110.8_586.
PMID:2273450
Abstract
A new tracer technique, in which a 13C-labeled compound as a biological tracer and 13C nuclear magnetic resonance (NMR) as an analytical tool are used, is proposed. In order to verify the applicability of the method to clinical chemistry. [1-13C]benzoic acid was administered and [1'-13C]hippuric acid excreted in the urine was quantitated by NMR, by using [1-13C]hippuric acid as an internal standard.
摘要
提出了一种新的示踪技术，该技术使用一种13C标记的化合物作为生物示踪剂，并使用13C核磁共振（NMR）作为分析工具。为了验证该方法在临床化学中的适用性，给予[1-13C]苯甲酸，并以[1-13C]马尿酸作为内标，通过NMR对尿液中排泄的[1'-13C]马尿酸进行定量。
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