Kudoh I, Andoh T, Kaneko K, Doi H, Okutsu Y, Okumura F
Department of Anesthesiology, Yokohama City University School of Medicine.
Masui. 1990 Nov;39(11):1509-13.
In negative extra-thoracic pressure ventilation (NETPV), lung water volume and central blood volume (CBV) could increase because of increased venous return and intensified negative interstitial pressure. The effects of NETPV on the extravascular lung water and CBV were examined in ten normal dogs by the double-indicator method using Na and cold water. The lung water volume measured by the method (EVTV) was compared with the lung water volume measured by the gravimetric method (EVLW) in 17 dogs. EVTV did not show any significant change in any ventilation modes compared with IPPV. CBV decreased from 21.9 ml.kg-1 to 19.2 ml.kg-1 in CPPV compared with IPPV (P less than 0.05). EVTV correlated well (r = 0.91, P less than 0.001) with EVLW. In normal dogs, NETPV did not change the lung water volume and CBV. NETPV dogs do not seem to have any disadvantage in respect of lung water volume compared with conventional positive pressure ventilations.
在负压胸外通气（NETPV）中，由于静脉回心血量增加和间质负压增强，肺水量和中心血容量（CBV）可能会增加。采用钠和冷水双指示剂法，在10只正常犬中研究了NETPV对血管外肺水和CBV的影响。将17只犬采用该方法测量的肺水量（EVTV）与重量法测量的肺水量（EVLW）进行比较。与间歇正压通气（IPPV）相比，EVTV在任何通气模式下均未显示出任何显著变化。与IPPV相比，持续气道正压通气（CPPV）时CBV从21.9 ml.kg-1降至19.2 ml.kg-1（P<0.05）。EVTV与EVLW相关性良好（r = 0.91，P<0.001）。在正常犬中，NETPV不会改变肺水量和CBV。与传统正压通气相比，NETPV犬在肺水量方面似乎没有任何劣势。
