Second Department of Radiology, Athens University School of Medicine, Attikon University Hospital, 12462, Athens, Greece.
Cardiovasc Intervent Radiol. 2013 Feb;36(1):183-91. doi: 10.1007/s00270-012-0379-z. Epub 2012 Jun 27.
To compare safety and efficacy of percutaneous vertebroplasty (PVP) when treating up to three vertebrae or more than three vertebrae per session.
We prospectively compared two groups of patients with symptomatic vertebral fractures who had no significant response to conservative therapy. Pathologic substrate included osteoporosis (n = 77), metastasis (n = 24), multiple myeloma (n = 13), hemangioma (n = 15), and lymphoma (n = 1). Group A patients (n = 94) underwent PVP of up to three treated vertebrae (n = 188). Group B patients (n = 36) underwent PVP with more than three treated vertebrae per session (n = 220). Decreased pain and improved mobility were recorded the day after surgery and at 12 and 24 months after surgery per clinical evaluation and the use of numeric visual scales (NVS): the Greek Brief Pain Inventory, a linear analogue self-assessment questionnaire, and a World Health Organization questionnaire.
Group A presented with a mean pain score of 7.9 ± 1.1 NVS units before PVP, which decreased to 2.1 ± 1.6, 2.0 ± 1.5 and 2.0 ± 1.5 NVS units the day after surgery and at 12 and 24 months after surgery, respectively. Group B presented with a mean pain score of 8.1 ± 1.3 NVS units before PVP, which decreased to 2.2 ± 1.3, 2.0 ± 1.5, and 2.1 ± 1.6 NVS units the day after surgery and at 12 and 24 months after surgery, respectively. Overall pain decrease and mobility improvement throughout the follow-up period presented no statistical significance neither between the two groups nor between different underlying aetiology. Reported cement leakages presented no statistical significance between the two groups (p = 0.365).
PVP is an efficient and safe technique for symptomatic vertebral fractures independently of the vertebrae number treated per session.
比较单次治疗最多 3 个椎体或超过 3 个椎体的经皮椎体成形术（PVP）的安全性和疗效。
我们前瞻性比较了两组接受保守治疗无明显反应的症状性椎体骨折患者。病理基础包括骨质疏松症（n=77）、转移瘤（n=24）、多发性骨髓瘤（n=13）、血管瘤（n=15）和淋巴瘤（n=1）。A 组患者（n=94）行最多 3 个治疗椎体的 PVP（n=188）。B 组患者（n=36）行单次治疗超过 3 个椎体的 PVP（n=220）。术后第 1 天、术后 12 个月和 24 个月，根据临床评估和数字视觉量表（NVS）记录疼痛减轻和活动度改善情况：希腊简明疼痛量表、线性模拟自我评估问卷和世界卫生组织问卷。
A 组患者 PVP 前平均疼痛评分为 7.9±1.1 NVS 单位，术后第 1 天、术后 12 个月和 24 个月分别降至 2.1±1.6、2.0±1.5 和 2.0±1.5 NVS 单位。B 组患者 PVP 前平均疼痛评分为 8.1±1.3 NVS 单位，术后第 1 天、术后 12 个月和 24 个月分别降至 2.2±1.3、2.0±1.5 和 2.1±1.6 NVS 单位。整个随访期间，两组间以及不同基础病因间的总体疼痛减轻和活动度改善均无统计学意义。两组间报告的水泥渗漏无统计学意义（p=0.365）。
PVP 是一种治疗症状性椎体骨折的有效且安全的技术，与单次治疗的椎体数量无关。
