University of Texas at Austin, Department of Chemistry and Biochemistry, 1 University Station-A5300, Austin, TX 78712-1167, USA.
Angew Chem Int Ed Engl. 2012 Jul 27;51(31):7830-4. doi: 10.1002/anie.201203334. Epub 2012 Jun 26.
It takes alkynes! Exposure of propargyl chlorides to primary benzylic alcohols in the presence of [Ir(cod){(R)-segphos}]OTf (cod = 1,5-cyclooctadiene, segphos = 5,5'-bis(diphenylphosphino)-4,4'-bi-1,3-benzodioxole, Tf = trifluoromethanesulfonyl) results in hydrogen exchange to give allenyliridium-aldehyde pairs that combine to form products of propargylation with high ee value (see scheme). The reaction can also be conducted using aldehydes.
需要炔烃！在[Ir(cod){(R)-segphos}]OTf（cod = 1,5-环辛二烯，segphos = 5,5'-双（二苯基膦基）-4,4'-联-1,3-苯并二恶唑，Tf = 三氟甲磺酸）存在下，将丙炔基氯化物暴露于伯苄基醇中，导致氢交换生成烯丙基铱-醛对，它们结合形成具有高对映选择性的丙炔化产物（见方案）。该反应也可以使用醛进行。
