Oizumi K, Nishino H, Miyake S, Shiga H, Sada T, Miyamoto M, Koike H
Sankyo Biological Research Laboratories, Sankyo Co., Ltd., Tokyo, Japan.
Jpn J Pharmacol. 1990 Sep;54(1):1-6. doi: 10.1254/jjp.54.1.
To investigate the central and regional hemodynamics after long-term administration of CS-905, a novel calcium blocker, we administered the agent (1 and 3 mg/kg/day) for 15 weeks in spontaneously hypertensive rats. At the end of the dosing period, hemodynamic changes were examined using the radioactive microsphere technique. CS-905 produced a sustained dose-dependent antihypertensive effect without inducing tolerance during the 15-week dosing period and prevented cardiac hypertrophy. The agent increased cardiac output, decreased blood pressure and thus decreased total peripheral resistance in a dose-related manner. Regional blood flows measured by the microsphere technique were increased in the kidney and brain despite the lowered blood pressure. There was no organ where regional blood flow was decreased. These changes after chronic treatment with CS-905 would be beneficial in the long-term therapy of hypertension.
为研究新型钙阻滞剂CS - 905长期给药后的中枢和局部血流动力学，我们对自发性高血压大鼠连续15周给予该药物（1和3毫克/千克/天）。在给药期结束时，使用放射性微球技术检查血流动力学变化。CS - 905在15周给药期内产生持续的剂量依赖性降压作用，且未诱导耐受性，并预防了心脏肥大。该药物增加心输出量，降低血压，从而以剂量相关的方式降低总外周阻力。尽管血压降低，但通过微球技术测量的肾脏和大脑局部血流量增加。没有任何器官的局部血流量减少。CS - 905长期治疗后的这些变化对高血压的长期治疗有益。
