Ohshima N, Yamada T, Nakahara H, Yokoyama M, Tanabe S, Irie Y, Fujisawa T
Department of Cardiovascular Surgery, Dokkyo University Koshigaya Hospital.
Kyobu Geka. 1990 Dec;43(13):1060-6.
This report described a familial recurrent cardiac myxoma involving mother and daughter. The mother, at 27 year of age, had developed recurrent multiple myxomas in both left and right atrium and right ventricle 4 years after surgical excision of left atrial myxoma. Excision was successful and remains well without signs of recurrence 9 years postoperatively. In an asymptomatic 13-year-old daughter, a recurrent left atrial myxoma was found 3 years after the excision of right atrial myxoma by echocardiographic follow-up at 6 month intervals. Excision of left atrial myxoma was performed and histology showed the essentially the same findings as primary myxoma without signs of malignancy. From an experience of this familial recurrent myxoma and a review of 38 cases of 17 familial cardiac myxoma, it is recommended that wide excision of tumor including surrounding tissues, thorough search for multiple heterotopic tumors at surgery, close postoperative echocardiographic follow-up for at least 5 years, and examination of skin and breast tumor, and endocrine disorder for "complex" myxoma.
本报告描述了一例涉及母女的家族性复发性心脏黏液瘤。母亲27岁时，在左心房黏液瘤手术切除4年后，左、右心房及右心室出现复发性多发性黏液瘤。手术切除成功，术后9年情况良好，无复发迹象。在无症状的13岁女儿中，右心房黏液瘤切除术后3年，通过每6个月一次的超声心动图随访发现复发性左心房黏液瘤。进行了左心房黏液瘤切除术，组织学检查显示与原发性黏液瘤基本相同，无恶性迹象。基于这例家族性复发性黏液瘤的经验以及对17个家族性心脏黏液瘤的38例病例回顾，建议广泛切除肿瘤包括周围组织，术中彻底寻找多发异位肿瘤，术后至少5年进行密切的超声心动图随访，以及对“复杂性”黏液瘤检查皮肤和乳腺肿瘤及内分泌紊乱情况。
