Ahn Grace E, Ramsey-Goldman Rosalind
Division of Rheumatology, Northwestern University, 240 E. Huron St. McGaw M300, Chicago, IL 6061, USA.
Int J Clin Rheumtol. 2012 Apr 1;7(2):217-227. doi: 10.2217/IJR.12.4.
Systemic lupus erythematosus is a chronic inflammatory autoimmune disease often characterized by fatigue, with significant effects on physical functioning and wellbeing. The definition, prevalence and factors associated with fatigue, including physical activity, obesity, sleep, depression, anxiety, mood, cognitive dysfunction, vitamin D deficiency/insufficiency, pain, effects of medications and comorbidities, as well as potential therapeutic options of fatigue in the systemic lupus erythematosus population are reviewed. Due to variability in the reliability and validity of various fatigue measures used in clinical studies, clinical trial data have been challenging to interpret. Further investigation into the relationships between these risk factors and fatigue, and improved measures of fatigue, may lead to an improvement in the management of this chronic inflammatory disease.
系统性红斑狼疮是一种慢性炎症性自身免疫性疾病，常以疲劳为特征，对身体功能和健康有重大影响。本文综述了疲劳的定义、患病率及相关因素，包括体力活动、肥胖、睡眠、抑郁、焦虑、情绪、认知功能障碍、维生素D缺乏/不足、疼痛、药物作用和合并症，以及系统性红斑狼疮患者疲劳的潜在治疗选择。由于临床研究中使用的各种疲劳测量方法在可靠性和有效性方面存在差异，临床试验数据难以解释。进一步研究这些危险因素与疲劳之间的关系，并改进疲劳测量方法，可能会改善这种慢性炎症性疾病的管理。
