Smetnev A S, Kadyrova M M, Sobol' Iu S, Sokolov S F, Ageev F T, Rogoza A N, Gorshkov A Sh
Kardiologiia. 1990 Sep;30(9):32-4.
In atrial fibrillation, allapinine was shown to enhance rhythm by 7% and to increase cardiac output (p less than 0.05), as well as to slightly lower mean blood pressure and peripheral vascular resistance at rest. With exercise, both in atrial fibrillation, and sinus rhythm, there was a decrease in end-diastolic and end-systolic volumes of the left ventricle (p less than 0.05), a slight drop in ventricular ejection, that was statistically significant only with sinus rhythm (p less than 0.05). Physical exercise was not followed by an apparent additional aggravation of myocardial contractility, which makes allapinine preferable for long-term application to preserve sinus rhythm in patients without evident signs of heart failure.
在心房颤动中，阿那匹宁可使心律提高7%，心输出量增加（p<0.05），同时在静息状态下可使平均血压和外周血管阻力略有降低。运动时，无论是心房颤动还是窦性心律，左心室舒张末期和收缩末期容积均减小（p<0.05），心室射血略有下降，仅在窦性心律时具有统计学意义（p<0.05）。体育锻炼后心肌收缩力无明显额外加重，这使得阿那匹宁更适合长期应用于无明显心力衰竭迹象的患者以维持窦性心律。
