Pavlov A V
Kardiologiia. 1990 Sep;30(9):37-40.
Acute intravenous administration of cordarone in a dose of 5 mg/kg was demonstrated to decrease the mean values of the peak increase rate in left ventricular pressure, circulatory myocardial fiber shortening velocity, ejection fraction, and specific peripheral vascular resistance by 19.5, 12.3, 10.3, and 26.2%, respectively. Less marked changes occurred in stroke and cardiac outputs. The effects were more pronounced during a more rapid intravenous administration of the agent, as well as in patients with lower myocardial contractility. Chronic administration of oral cordarone in doses of 200 to 300 mg a day had a low effect on cardiac hemodynamic parameters. Sinus bradycardia was significant in reducing the cardiac output (-10.8%). All the patients displayed prolonged Q-T interval that was maximally apparent in patients with the baseline prolonged interval (+13.1%).
静脉注射剂量为5mg/kg的可达龙，结果显示可使左心室压力峰值上升速率、循环心肌纤维缩短速度、射血分数及特定外周血管阻力的平均值分别降低19.5%、12.3%、10.3%和26.2%。心搏量和心输出量的变化不太明显。在更快速静脉注射该药时，以及心肌收缩力较低的患者中，这些效应更为显著。每天口服200至300mg可达龙进行长期给药，对心脏血流动力学参数的影响较小。窦性心动过缓对心输出量的降低作用显著（-10.8%）。所有患者的Q-T间期均延长，在基线间期延长的患者中最为明显（+13.1%）。
