焦虑症患者在注意力负荷下杏仁核对威胁的激活。
Amygdala activation to threat under attentional load in individuals with anxiety disorder.
作者信息
Straube Thomas, Lipka Judith, Sauer Andreas, Mothes-Lasch Martin, Miltner Wolfgang Hr
机构信息
Department of Biological and Clinical Psychology, Friedrich-Schiller-University, Jena, Germany.
出版信息
Biol Mood Anxiety Disord. 2011 Dec 16;1(1):12. doi: 10.1186/2045-5380-1-12.
BACKGROUND
Previous studies in healthy subjects have shown that strong attentional distraction prevents the amygdala from responding to threat stimuli. Here, we investigated the effects of attentional load on amygdala activation to threat-related stimuli in individuals suffering from an anxiety disorder.
METHODS
During functional magnetic resonance imaging, spider-phobicand healthy control subjects were presented with phobia-related and neutral stimuli while performing a distraction task with varying perceptual load (high vs low).
RESULTS
Our data revealed a pattern of simultaneously increased amygdala and visual cortical activation to threat vs neutral pictures in phobic individuals, compared with controls, occurring regardless of attentional load.
CONCLUSIONS
These results suggest that, in contrast to studies in healthy subjects, amygdala activation to clinically relevant threat stimuli is more resistant to attentional load.
背景
先前针对健康受试者的研究表明，强烈的注意力分散可阻止杏仁核对威胁刺激作出反应。在此，我们调查了注意力负荷对患有焦虑症的个体的杏仁核激活与威胁相关刺激的影响。
方法
在功能磁共振成像期间，向蜘蛛恐惧症患者和健康对照受试者呈现与恐惧症相关和中性的刺激，同时进行具有不同感知负荷（高与低）的分心任务。
结果
我们的数据显示，与对照组相比，恐惧症患者在面对威胁图片与中性图片时，杏仁核和视觉皮层的激活同时增加，且这一情况与注意力负荷无关。
结论
这些结果表明，与针对健康受试者的研究不同，杏仁核对临床相关威胁刺激的激活对注意力负荷更具抗性。
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