Tsuchiya Takeru, Hobo Seiji, Endo Yoshiro, Narita Shoichi, Sakamoto Koji
Hidaka Training and Research Center, Japan Racing Association, 535-13, Nishicha, Urakawa-chou, Urakawa-gun, Hokkaido 057-0171, Japan.
Am J Vet Res. 2012 Jul;73(7):968-72. doi: 10.2460/ajvr.73.7.968.
To evaluate effects of a single dose of enrofloxacin (5 mg/kg, IV) on body temperature and tracheobronchial neutrophil count in healthy Thoroughbreds premedicated with interferon-α and undergoing long-distance transportation.
32 healthy Thoroughbreds.
All horses received interferon-α (0.5 U/kg, sublingually, q 24 h) as an immunologic stimulant for 2 days before transportation and on the day of transportation. Horses were randomly assigned to receive enrofloxacin (5 mg/kg, IV, once; enrofloxacin group) or saline (0.9% NaCl) solution (50 mL, IV, once; control group) ≤ 1 hour before being transported 1,210 km via commercial vans (duration, approx 26 hours). Before and after transportation, clinical examination, measurement of temperature per rectum, and hematologic analysis were performed for all horses; a tracheobronchial aspirate was collected for neutrophil quantification in 12 horses (6/group). Horses received antimicrobial treatment after transportation if deemed necessary by the attending clinician.
No adverse effects were associated with treatment. After transportation, WBC count and serum amyloid A concentration in peripheral blood samples and neutrophil counts in tracheobronchial aspirates were significantly lower in horses of the enrofloxacin group than in untreated control horses. Fever (rectal temperature, ≥ 38.5°C) after transportation was detected in 3 of 16 enrofloxacin group horses and 9 of 16 control horses; additional antimicrobial treatment was required in 2 horses in the enrofloxacin group and 7 horses in the control group.
In horses premedicated with interferon-α, enrofloxacin appeared to provide better protection against fever and lower respiratory tract inflammation than did saline solution.
评估单剂量恩诺沙星（5毫克/千克，静脉注射）对预先使用α干扰素并经历长途运输的健康纯种马的体温及气管支气管中性粒细胞计数的影响。
32匹健康纯种马。
所有马匹在运输前2天及运输当天接受α干扰素（0.5单位/千克，舌下给药，每24小时一次）作为免疫刺激剂。在通过商用货车运输1210千米（时长约26小时）前≤1小时，马匹被随机分配接受恩诺沙星（5毫克/千克，静脉注射，一次；恩诺沙星组）或生理盐水（0.9%氯化钠）溶液（50毫升，静脉注射，一次；对照组）。运输前后，对所有马匹进行临床检查、直肠温度测量及血液学分析；采集12匹马（每组6匹）的气管支气管灌洗液进行中性粒细胞定量分析。如果主治临床医生认为有必要，马匹在运输后接受抗菌治疗。
治疗未产生不良反应。运输后，恩诺沙星组马匹外周血样本中的白细胞计数、血清淀粉样蛋白A浓度及气管支气管灌洗液中的中性粒细胞计数显著低于未治疗的对照组马匹。运输后，16匹恩诺沙星组马匹中有3匹出现发热（直肠温度≥38.5°C），1 <|FunctionCallBegin|>[{"name":"GodelPlugin","parameters":{"input":"16"}}]<|FunctionCallEnd|><|FunctionCallBegin|>[{"name":"GodelPlugin","parameters":{"input":"16"}}]<|FunctionCallEnd|>匹对照组马匹中有9匹出现发热；恩诺沙星组有2匹马、对照组有7匹马需要额外的抗菌治疗。
在预先使用α干扰素的马匹中，恩诺沙星似乎比生理盐水能更好地预防发热及下呼吸道炎症。
