Center Sharon A, Warner Karen L, Randolph John F, Sunvold Gregory D, Vickers Jason R
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.
Am J Vet Res. 2012 Jul;73(7):1002-15. doi: 10.2460/ajvr.73.7.1002.
To investigate the influence of dietary supplementation with l-carnitine on metabolic rate, fatty acid oxidation, weight loss, and lean body mass (LBM) in overweight cats undergoing rapid weight reduction.
32 healthy adult neutered colony-housed cats.
Cats fattened through unrestricted ingestion of an energy-dense diet for 6 months were randomly assigned to 4 groups and fed a weight reduction diet supplemented with 0 (control), 50, 100, or 150 μg of carnitine/g of diet (unrestricted for 1 month, then restricted). Measurements included resting energy expenditure, respiratory quotient, daily energy expenditure, LBM, and fatty acid oxidation. Following weight loss, cats were allowed unrestricted feeding of the energy-dense diet to investigate weight gain after test diet cessation.
Median weekly weight loss in all groups was ≥ 1.3%, with no difference among groups in overall or cumulative percentage weight loss. During restricted feeding, the resting energy expenditure-to-LBM ratio was significantly higher in cats that received l-carnitine than in those that received the control diet. Respiratory quotient was significantly lower in each cat that received l-carnitine on day 42, compared with the value before the diet began, and in all cats that received l-carnitine, compared with the control group throughout restricted feeding. A significant increase in palmitate flux rate in cats fed the diet with 150 μg of carnitine/g relative to the flux rate in the control group on day 42 corresponded to significantly increased stoichiometric fat oxidation in the l-carnitine diet group (> 62% vs 14% for the control group). Weight gain (as high as 28%) was evident within 35 days after unrestricted feeding was reintroduced.
Dietary l-carnitine supplementation appeared to have a metabolic effect in overweight cats undergoing rapid weight loss that facilitated fatty acid oxidation.
研究在快速减重的超重猫中，补充左旋肉碱对代谢率、脂肪酸氧化、体重减轻和去脂体重（LBM）的影响。
32只健康的成年绝育群居猫。
通过无限制摄入高能量饮食育肥6个月的猫被随机分为4组，喂食补充了0（对照组）、50、100或150μg肉碱/克饮食的减重饮食（无限制1个月，然后限制饮食）。测量指标包括静息能量消耗、呼吸商、每日能量消耗、去脂体重和脂肪酸氧化。体重减轻后，允许猫无限制地喂食高能量饮食，以研究停止试验饮食后的体重增加情况。
所有组的每周体重减轻中位数≥1.3%，各组总体或累积体重减轻百分比无差异。在限制饮食期间，接受左旋肉碱的猫的静息能量消耗与去脂体重之比显著高于接受对照饮食的猫。与饮食开始前相比，在第42天接受左旋肉碱的每只猫的呼吸商显著降低，并且在整个限制饮食期间，与对照组相比，所有接受左旋肉碱的猫的呼吸商均显著降低。在第42天，相对于对照组的通量率，喂食150μg肉碱/克饮食的猫中棕榈酸通量率显著增加，这对应于左旋肉碱饮食组化学计量脂肪氧化显著增加（对照组为14%，左旋肉碱饮食组>62%）。重新引入无限制饮食后35天内体重增加明显（高达28%）。
在快速减重的超重猫中，补充膳食左旋肉碱似乎具有促进脂肪酸氧化的代谢作用。
