Friend M, Lee J S
Department of Biomedical Engineering, University of Virginia, Charlottesville 22908.
J Biomech Eng. 1990 Nov;112(4):451-6. doi: 10.1115/1.2891210.
Based on the relation between the red blood cell velocity and the blood velocity of the Fahraeus effect, we analyze the motion of a red blood cell in a deforming capillary to investigate how the ventilatory induced deformation affects the transit of the red blood cell through the pulmonary capillary and changes the hematocrit discharged from the capillary. An analytical solution is also obtained for the case of an infinitesimal deformation. The numerical and analytic solutions demonstrate that the variation in discharge hematocrit is proportional to the change of pulmonary capillary blood volume between the time that the red cell enters and the time that it exits the capillary. We also find that this hematocrit variation could be regarded, in terms of transport, to originate from the mid-section of the capillary.
基于红细胞速度与法厄效应血流速度之间的关系,我们分析了变形毛细血管中红细胞的运动,以研究通气引起的变形如何影响红细胞通过肺毛细血管的传输,并改变从毛细血管排出的血细胞比容。对于无限小变形的情况,还得到了一个解析解。数值解和解析解表明,排出血细胞比容的变化与红细胞进入毛细血管到离开毛细血管这段时间内肺毛细血管血容量的变化成正比。我们还发现,从传输的角度来看,这种血细胞比容变化可能源于毛细血管的中间部分。