Autophagy. 2012 Aug;8(8):1169-74. doi: 10.4161/auto.20788. Epub 2012 Jun 28.
One of the most exciting aspects of autophagy is its connection with aging, and the possibility of manipulating autophagy to extend life span. Many studies now demonstrate a general decrease in autophagy with age and offer some very interesting indications that reversing this trend, either genetically or pharmacologically, can have a beneficial effect with regard to aging. One of the first researchers to consider the connection between diet, aging and autophagy is Ettore Bergamini, the subject of this interview.
自噬最令人兴奋的方面之一是它与衰老的联系，以及操纵自噬以延长寿命的可能性。现在许多研究表明，随着年龄的增长，自噬普遍减少，并提供了一些非常有趣的迹象，表明无论是通过遗传还是药理学逆转这种趋势，都可以对衰老产生有益的影响。最早考虑饮食、衰老和自噬之间联系的研究人员之一是 Ettore Bergamini，本次采访的主题。
