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Metformin and rapamycin have distinct effects on the AKT pathway and proliferation in breast cancer cells.二甲双胍和雷帕霉素对乳腺癌细胞的 AKT 通路和增殖有明显的影响。
Breast Cancer Res Treat. 2010 Aug;123(1):271-9. doi: 10.1007/s10549-010-0763-9. Epub 2010 Feb 5.
2
[Celecoxib promotes apoptosis of breast cancer cell line MDA-MB-231 through down-regulation of the NF-kappaB pathway].[塞来昔布通过下调NF-κB通路促进乳腺癌细胞系MDA-MB-231凋亡]
Ai Zheng. 2009 Jun;28(6):569-74.
3
Metformin and pathologic complete responses to neoadjuvant chemotherapy in diabetic patients with breast cancer.二甲双胍与糖尿病乳腺癌患者对新辅助化疗的病理完全缓解
J Clin Oncol. 2009 Jul 10;27(20):3297-302. doi: 10.1200/JCO.2009.19.6410. Epub 2009 Jun 1.
4
The insulin-like growth factor-I receptor as an oncogene.作为癌基因的胰岛素样生长因子-I受体。
Arch Physiol Biochem. 2009 May;115(2):58-71. doi: 10.1080/13813450902783106.
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Prevention of ER-negative breast cancer.雌激素受体阴性乳腺癌的预防
Recent Results Cancer Res. 2009;181:121-34. doi: 10.1007/978-3-540-69297-3_13.
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Membranous and cytoplasmic staining of Ki67 is associated with HER2 and ER status in invasive breast carcinoma.在浸润性乳腺癌中，Ki67的膜性和胞质染色与HER2及雌激素受体（ER）状态相关。
Histopathology. 2009 Jan;54(2):254-7. doi: 10.1111/j.1365-2559.2008.03191.x.
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Aspisol inhibits tumor growth and induces apoptosis in breast cancer.阿斯匹索尔可抑制乳腺癌肿瘤生长并诱导其凋亡。
Exp Oncol. 2008 Dec;30(4):289-94.
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Phosphorylated insulin-like growth factor-i/insulin receptor is present in all breast cancer subtypes and is related to poor survival.磷酸化胰岛素样生长因子 -i/胰岛素受体存在于所有乳腺癌亚型中，且与生存率低相关。
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Bax expression in untreated breast cancer: an immunocytometric study of 255 cases.未经治疗的乳腺癌中 Bax 蛋白的表达：255 例病例的免疫细胞化学研究
Anticancer Res. 2008 Sep-Oct;28(5A):2595-8.
10
Cross-talk between the ErbB/HER family and the type I insulin-like growth factor receptor signaling pathway in breast cancer.乳腺癌中ErbB/HER家族与I型胰岛素样生长因子受体信号通路之间的相互作用。
J Mammary Gland Biol Neoplasia. 2008 Dec;13(4):485-98. doi: 10.1007/s10911-008-9107-3. Epub 2008 Nov 25.

乳腺癌中环氧合酶-2与胰岛素样生长因子之间的相互作用：预防与治疗的新领域。

Interaction between cyclooxygenase-2 and insulin-like growth factor in breast cancer: A new field for prevention and treatment.

作者信息

Taromaru Giuliana Cássia Morrone, DE Oliveira Vilmar Marques, Silva Maria Antonieta Longo Galvão, Montor Wagner Ricardo, Bagnoli Fabio, Rinaldi José Francisco, Aoki Tsutomu

机构信息

Department of Obstetrics and Gynecology, Irmandade da Santa Casa de Misericórdia de São Paulo and Santa Casa de São Paulo, Faculty of Medical Sciences, São Paulo, Brazil.

出版信息

Oncol Lett. 2012 Mar;3(3):682-688. doi: 10.3892/ol.2011.532. Epub 2011 Dec 21.

DOI:10.3892/ol.2011.532
PMID:22740976
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3362482/
Abstract

The objective of this study was to evaluate the correlation between cyclooxygenase-2 (COX-2) and markers of cell proliferation and apoptosis, including, Bcl-2, Bax, Ki-67 and the type I insulin-like growth factor (IGF) receptor (IGF1-R) in ductal carcinoma in situ (DCIS) and infiltrating ductal carcinoma (IDC), present in the same surgical specimen. A total of 110 cases were evaluated using tissue microarrays. Cases were classified in scores from 0 to 3 according to pre-defined methods. The results showed that the positivity rates were COX-2 in 87% of cases in DCIS and IDC; Bcl-2 in 55% of cases in DCIS and IDC; Bax in 23% of cases in IDC and 19% in DCIS, IGF-1 in 24% of cases in DCIS and IDC; and Ki-67 in 81% of cases in DCIS and IDC. We also observed a positive correlation between the expression of COX-2 and IGF1-R (p=0.045). Our results demonstrate a positive correlation between the expression of COX-2 and IGF1-R in DCIS and IDC, demonstrating that they are involved in breast cancer carcinogenesis. Further studies are required to prove the effectiveness of COX-2 and IGF1-R inhibitors for the prevention and treatment of breast cancer, as well as to explain their mechanism of action.

摘要

本研究的目的是评估同一手术标本中导管原位癌（DCIS）和浸润性导管癌（IDC）中环氧化酶-2（COX-2）与细胞增殖和凋亡标志物之间的相关性，这些标志物包括Bcl-2、Bax、Ki-67和I型胰岛素样生长因子（IGF）受体（IGF1-R）。使用组织微阵列对总共110例病例进行了评估。根据预定义方法将病例分为0至3分。结果显示，DCIS和IDC中COX-2的阳性率为87%；DCIS和IDC中Bcl-2的阳性率为55%；IDC中Bax的阳性率为23%，DCIS中为19%；DCIS和IDC中IGF-1的阳性率为24%；DCIS和IDC中Ki-67的阳性率为81%。我们还观察到COX-2与IGF1-R的表达之间存在正相关（p=0.045）。我们的结果表明，DCIS和IDC中COX-2与IGF1-R的表达之间存在正相关，表明它们参与了乳腺癌的致癌过程。需要进一步研究以证明COX-2和IGF1-R抑制剂对乳腺癌预防和治疗的有效性，并解释其作用机制。