RadioRx, Inc, Mountain View, CA.
Transl Oncol. 2012 Jun;5(3):133-40. doi: 10.1593/tlo.12118. Epub 2012 Jun 1.
This review attempts to move beyond the traditional borders of antiangiogenesis and toward the dynamic, evolving strategies of vascular modulation. This repositioning entails a two-fold paradigm shift: conceptually, to a view of antiangiogenesis as only one part of a larger story, and therapeutically, to approaches which attempt to modulate tumor blood flow instead of simply inhibiting it. Three vascular modulation strategies-provascular, antivascular, and redistributive-are presented with representative compounds. These vascular modulation strategies are described in specific measurable characteristics (blood vessel maturity and type, effect on blood flow, microenvironmental target, molecular target, angiogenic biomarker, and imaging biomarkers) that will help define the tumor types that are more susceptible to a particular vascular modulation strategy thereby guiding therapeutic agent selection and enabling a personalized medicine approach.
这篇综述试图超越传统的抗血管生成治疗边界，朝着血管调节的动态、演进策略发展。这种重新定位需要双重范式转变：从概念上看，将抗血管生成视为更大故事的一部分；从治疗角度来看，采用试图调节肿瘤血流而不仅仅是抑制它的方法。本文提出了三种血管调节策略——促血管生成、抗血管生成和再分配，并介绍了代表性化合物。这些血管调节策略具有明确的可测量特征（血管成熟度和类型、对血流的影响、微环境靶点、分子靶点、血管生成生物标志物和成像生物标志物），有助于确定更易受特定血管调节策略影响的肿瘤类型，从而指导治疗药物的选择，并实现个体化医疗方法。
