Faculty of Science, Institute of Evolution, University of Haifa, Mount Carmel, Haifa, 31905, Israel.
Anim Genet. 2012 Jul;43 Suppl 1:36-44. doi: 10.1111/j.1365-2052.2012.02347.x.
In this paper, we review some approaches for QTL mapping developed by our research group in collaboration with, following the recommendation of, or under inspiration of Moshe Soller. Specifically, we explain at a simple intuitive level the main principles and ideas of: (a) QTL mapping by fractioned DNA pooling, (b) increasing the detection power of QTL mapping (in the case of individual genotyping) by multiple-trait analysis, and (c) the role of variance-covariance effects in QTL mapping. On each of these themes we had long and deep discussions with Soller on the statistical aspects of the proposed procedures. We hope that together we made important contributions towards making QTL mapping procedures easier and more effective.
在本文中，我们回顾了我们的研究小组与 Moshe Soller 合作、遵循其建议或受其启发而开发的一些 QTL 作图方法。具体来说，我们在一个简单直观的层面上解释了以下方法的主要原理和思路：（a）基于分片段 DNA 池的 QTL 作图，（b）通过多性状分析提高 QTL 作图（在个体基因型分析的情况下）的检测能力，以及（c）方差-协方差效应对 QTL 作图的作用。在这些主题中的每一个主题上，我们都与 Soller 进行了关于所提出的程序的统计方面的长时间和深入的讨论。我们希望我们一起为使 QTL 作图程序更加容易和有效做出了重要贡献。
