Department of Cardiology, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, Guangzhou 510120, China.
Med Hypotheses. 2012 Sep;79(3):381-3. doi: 10.1016/j.mehy.2012.05.042. Epub 2012 Jun 27.
Carbohydrate antigen 125 has been known as a membrane-associated mucin. It has found application as a tumor marker that may be elevated in the blood of some patients with ovarian cancer, or other benign conditions. Recently, increased serum carbohydrate antigen 125 levels have been documented in patients with heart failure. However, little is known about the pathophysiologic mechanism. It has been found that carbohydrate antigen 125 will be shed from surfaces of mesothelial cells in response to mechanical stress such as fluid overload, and inflammatory stimuli. High carbohydrate antigen 125 levels are closely related to the presence of serosal fluid and positively correlated with serum TNF-α, IL-6 and IL-10 levels in heart failure patients. This leads to proposed hypothesis that the mechanical stress and inflammatory stimuli both initiate carbohydrate antigen 125 synthesis. This finding suggests that carbohydrate antigen 125 might be a promising biomarker to evaluate the risk stratification of heart failure and monitor the process of therapy.
糖类抗原 125 是一种膜结合型黏蛋白，已被用作肿瘤标志物，在一些卵巢癌或其他良性疾病患者的血液中可能升高。最近，心力衰竭患者的血清糖类抗原 125 水平升高已被记录。然而，其病理生理机制知之甚少。已经发现，糖类抗原 125 会从间皮细胞表面脱落，以响应诸如液体过载和炎症刺激等机械应激。高糖类抗原 125 水平与浆膜液的存在密切相关，并与心力衰竭患者的血清 TNF-α、IL-6 和 IL-10 水平呈正相关。这导致了一个假设，即机械应激和炎症刺激都启动了糖类抗原 125 的合成。这一发现表明，糖类抗原 125 可能是评估心力衰竭风险分层和监测治疗过程的有前途的生物标志物。
