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清道夫受体 A 配体诱导 IL1β 的分泌，并对培养的星形胶质细胞的炎症激活产生调节作用。

Scavenger receptor class A ligands induce secretion of IL1β and exert a modulatory effect on the inflammatory activation of astrocytes in culture.

机构信息

Departamento de Neurología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Marcoleta 391, Santiago, Chile.

出版信息

J Neuroimmunol. 2012 Oct 15;251(1-2):6-13. doi: 10.1016/j.jneuroim.2012.06.004. Epub 2012 Jun 26.

DOI:10.1016/j.jneuroim.2012.06.004
PMID:22743055
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3432714/
Abstract

Class-A scavenger receptor (SR-A) is expressed by microglia, and we show here that it is also expressed by astrocytes, where it participates on their inflammatory activation. Astrocytes play a key role on the inflammatory response of the central nervous system, secreting several soluble mediators like cytokines and radical species. Exposure to SR ligands activated MAPKs and NF-κB signaling and increased production of IL1β and nitric oxide (NO). IL1β classically an inflammatory cytokine surprisingly did not increase but inhibited LPS+IFNγ-induced NO production by astrocytes. Our results suggest that SRs expressed by astrocytes participate in the modulation of inflammatory activation.

摘要

I 类清道夫受体 (SR-A) 由小胶质细胞表达，我们在这里显示它也由星形胶质细胞表达，在星形胶质细胞中它参与其炎症激活。星形胶质细胞在中枢神经系统的炎症反应中发挥关键作用，分泌几种可溶性介质，如细胞因子和自由基。暴露于 SR 配体激活了 MAPKs 和 NF-κB 信号通路，并增加了 IL1β 和一氧化氮 (NO) 的产生。IL1β 是一种经典的炎症细胞因子，但令人惊讶的是，它并没有增加，反而抑制了 LPS+IFNγ 诱导的星形胶质细胞中 NO 的产生。我们的结果表明，星形胶质细胞表达的 SR 参与了炎症激活的调节。

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