Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, Republic of Korea.
Neurosci Lett. 2012 Aug 8;523(1):67-70. doi: 10.1016/j.neulet.2012.06.043. Epub 2012 Jun 26.
Many animal studies have reported on the neural connectivity of the inferior olivary nucleus (ION). However, the neural connectivity of the ION has not been clearly elucidated in the human brain. In this study, the neural connectivity of the ION in the human brain was investigated by diffusion tensor imaging (DTI).
Forty healthy subjects were recruited. DTIs were acquired using a sensitivity-encoding head coil at 1.5T. Connectivity was defined as the incidence of connection between the ION and regions of interest (ROIs) in the brain.
In these subjects, the ION showed higher connectivity to the reticular formation (100%), the posterior limb of internal capsule (100%), the red nucleus (93.75%), the cerebral peduncle of midbrain (91.25%), the primary motor cortex (86.25%), the primary somatosensory cortex (85%), the periaqueductal gray mater (81.25%), the globus pallidus (81.25%), the anterior limb of internal capsule (62.5%), the pontine basis (62.5%), and the posterior parietal cortex (60%).
The ION shows high connectivity with motor function-related areas, such as, the posterior limb of internal capsule, the red nucleus, the cerebral peduncle of midbrain, the primary motor cortex, and the pontine basis. These results indicate that the ION is closely related to motor function in the human brain.
许多动物研究报告了下橄榄核（ION）的神经连接。然而，ION 在人脑中的神经连接尚未清楚阐明。在这项研究中，通过弥散张量成像（DTI）研究了人脑 ION 的神经连接。
招募了 40 名健康受试者。使用头部敏感线圈在 1.5T 下采集 DTIs。连接性定义为 ION 与大脑中感兴趣区域（ROI）之间的连接发生率。
在这些受试者中，ION 与网状结构（100%）、内囊后肢（100%）、红核（93.75%）、中脑大脑脚（91.25%）、初级运动皮层（86.25%）、初级体感皮层（85%）、导水管周围灰质（81.25%）、苍白球（81.25%）、内囊前肢（62.5%）、脑桥基底（62.5%）和顶叶后皮质（60%）具有更高的连接性。
ION 与运动功能相关区域（如内囊后肢、红核、中脑大脑脚、初级运动皮层和脑桥基底）具有高度连接性。这些结果表明 ION 与人脑的运动功能密切相关。
