Quintyne Keith Ian, Baker Shirley, Wallis Fintan, Gupta Rajnish
Medical Oncology Department, Mid-Western Regional Hospital, and Stokes Research Institute, University of Limerick, Limerick, Ireland.
BMJ Case Rep. 2012 Jun 28;2012:bcr1120115202. doi: 10.1136/bcr.11.2011.5202.
The authors herein report the case of a 32-year-old man with advancing metastatic malignant melanoma, who has progressed through all previous lines of therapy, presenting with ongoing respiratory tract symptoms of exertional shortness of breath and cough. CT restaging confirmed clinical findings of deteriorating pulmonary disease; histological review revealed V600E BRAF mutation. He was started on targeted biological therapy with BRAF inhibitor GSK2118436, and is having a good clinical and radiological response without significant lasting toxicity.
本文作者报告了一例32岁进展期转移性恶性黑色素瘤男性患者的病例，该患者此前所有治疗方案均已无效，目前存在劳力性呼吸急促和咳嗽等持续呼吸道症状。CT重新分期证实了肺部疾病恶化的临床发现；组织学检查显示存在V600E BRAF突变。他开始接受BRAF抑制剂GSK2118436的靶向生物治疗，目前临床和影像学反应良好，且无明显的持续性毒性。
