Division of Nanomaterials and Chemistry, Hefei National Laboratory for Physical Sciences at Microscale, Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, PR China.
Chemistry. 2012 Jul 23;18(30):9294-9. doi: 10.1002/chem.201201173. Epub 2012 Jun 28.
Multifunctional Ag@Au@ phenol formaldehyde resin (PFR) particles loaded with folic acids (FA) have been designed for killing tumor cells through photothermy conversion under the irradiation of near-infrared (NIR) light. Possessing the virtue of good fluorescence, low toxicity, and good targeting, the nanocomposite consists of an Ag core, an Au layer, a PFR shell, and folic acids on the PFR shell. The Ag@PFR core-shell structure can be prepared with a simple hydrothermal method after preheating. We then filled the PFR shell with a layer of Au by heating and modified the shell with polyelectrolyte to change its surface charge state. To capture tumor cells actively, FA molecules were attached onto the surface of the Ag@Au@PFR particles in the presence of 1-ethyl-3-(3-dimethly aminopropyl) carbodiimide (EDAC) and N-hydroxysuccinimide (NHS). Owing to the excellent property of Au NPs and Ag NPs as photothermal conversion agents, the Ag@Au@ PFR@FA particles can be utilized to kill tumor cells when exposed to NIR light.
载有叶酸 (FA) 的多功能 Ag@Au@酚醛树脂 (PFR) 颗粒已被设计用于通过近红外 (NIR) 光照射下的光热转换来杀死肿瘤细胞。该纳米复合材料由 Ag 核、Au 层、PFR 壳和 PFR 壳上的叶酸组成，具有良好的荧光性、低毒性和良好的靶向性。Ag@PFR 核壳结构可以在预热后通过简单的水热法制备。然后，通过加热在 PFR 壳中填充一层 Au，并通过聚电解质对壳进行修饰来改变其表面电荷状态。为了主动捕获肿瘤细胞，在 1-乙基-3-(3-二甲氨基丙基)碳二亚胺 (EDAC) 和 N-羟基琥珀酰亚胺 (NHS) 的存在下，将 FA 分子连接到 Ag@Au@PFR 颗粒的表面上。由于 Au NPs 和 Ag NPs 作为光热转换剂的优异性能，Ag@Au@PFR@FA 颗粒在暴露于 NIR 光下时可用于杀死肿瘤细胞。
