MOE Key Laboratory for Standardization of Chinese Medicines and SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, The Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, PRC.
Phytother Res. 2013 Apr;27(4):618-23. doi: 10.1002/ptr.4771. Epub 2012 Jun 29.
Andrographolide (AND) and neoandrographolide (NEO) are the diterpenoids from the Andrographis paniculata (Acanthaceae). It is reported the diterpenoids exhibit a wide spectrum of biological activities. The aim of this study was to investigate the hypolipidemic effect of AND and NEO in hyperlipidemic mice induced by 75% yolk emulsion and in hyperlipidemic rats induced by high fat emulsion, respectively. The results showed that the levels of triglyceride, total cholesterol (TC) and low-density lipoprotein cholesterol were reduced by AND and NEO in a dose-dependent tendency in mice. Compared with the model group, the plasma TC levels of experimental groups with AND and NEO at 100 mg/kg dosage decreased by 23.9 and 20.2% in rats, respectively (P < 0.05). It was also found that the plasma aspartate transaminase and alanine transaminase levels were significantly decreased by feeding with AND and NEO in rats, compared with positive group (simvastatin) (P < 0.01). Otherwise, AND and NEO could protect the cardiovascular due to down-regulation of iNOS expression and up-regulation of eNOS expression. In conclusion, AND and NEO have potent hypolipidemic effects and protect the cardiovascular without significant liver damage.
穿心莲内酯（AND）和新穿心莲内酯（NEO）是穿心莲（爵床科）中的二萜类化合物。据报道，二萜类化合物具有广泛的生物活性。本研究旨在分别研究 AND 和 NEO 对蛋黄乳液 75%诱导的高血脂小鼠和高脂肪乳剂诱导的高血脂大鼠的降血脂作用。结果表明，AND 和 NEO 可降低小鼠体内甘油三酯、总胆固醇（TC）和低密度脂蛋白胆固醇水平，呈剂量依赖性。与模型组相比，AND 和 NEO 各 100mg/kg 剂量组大鼠 TC 水平分别下降 23.9%和 20.2%（P<0.05）。还发现，与阳性组（辛伐他汀）相比，AND 和 NEO 喂养可显著降低大鼠血浆天冬氨酸转氨酶和丙氨酸转氨酶水平（P<0.01）。此外，AND 和 NEO 可以通过下调 iNOS 表达和上调 eNOS 表达来保护心血管系统。综上所述，AND 和 NEO 具有较强的降血脂作用，且对心血管系统有保护作用，无明显肝损伤。
