抗层粘连蛋白IgG通过激活胆碱能系统释放血栓素B2。

Antilaminin IgG releases TXB2 through activation of the cholinergic system.

作者信息

Bacman S, Sterin-Borda L, Borda E

机构信息

Centro de Estudios Farmacológicos y de Principios Naturales (CEFAPRIN), Buenos Aires, Argentina.

出版信息

Prostaglandins Leukot Essent Fatty Acids. 1990 Oct;41(2):101-4. doi: 10.1016/0952-3278(90)90061-o.

DOI:10.1016/0952-3278(90)90061-o

PMID:2274567

Abstract

Antilaminin IgG was bound to cholinergic muscarinic receptors of normal mice heart and released TXB2, simulating the biological effect of a cholinergic agonist. Antilaminin IgG interfered with the binding of the radiolabelled muscarinis antagonist (-)3H-QNB in a noncompetitive fashion. Following the interaction of the antibody with the cholinergic receptor, an increased production of TXB2 occurred. This effect required the activation of the muscarinic cholinergic system, because it was blunted by atropine and mimicked by acetylcholine.

摘要

抗层粘连蛋白IgG与正常小鼠心脏的胆碱能毒蕈碱受体结合并释放血栓素B2（TXB2），模拟胆碱能激动剂的生物学效应。抗层粘连蛋白IgG以非竞争性方式干扰放射性标记的毒蕈碱拮抗剂（-）3H-QNB的结合。抗体与胆碱能受体相互作用后，TXB2的产生增加。这种效应需要毒蕈碱胆碱能系统的激活，因为它被阿托品减弱并被乙酰胆碱模拟。