Kishi Taro, Fukuo Yasuhisa, Okochi Tomo, Kawashima Kunihiro, Kitajima Tsuyoshi, Inada Toshiya, Ozaki Norio, Musso Giovanna M, Kane John M, Correll Christoph U, Iwata Nakao
Division of Psychiatry Research, The Zucker Hillside Hospital, Glen Oaks, NY 11004, USA.
Hum Psychopharmacol. 2012 Jan;27(1):63-9. doi: 10.1002/hup.1266.
Several lines of evidence suggest that genetic alterations in serotonin 6 (5-HT6) receptors might be associated with the pathophysiology of schizophrenia. We sought to assess the relationship between genotype alterations in 5-HT6 receptors and schizophrenia both in a case-control study and a meta-analysis.
We conducted an association study of the 5-HT6 receptor gene (HTR6) in Japanese patients with schizophrenia (n = 836) and controls (n = 857). Five tagging single-nucleotide polymorphisms (SNPs), including rs1805054 (C267T) in HTR6, were selected. In addition, we carried out a meta-analysis between rs1805054, which has been examined in other studies, and schizophrenia, searching PubMed through August 2011.
There were no significant associations between the tagging SNPs in HTR6 and schizophrenia in any of the genotype models in both the simple and the multiple logistic regression analyses correcting for potential confounds. Similarly, no significant association was found in the all-marker haplotype multiple logistic regression analysis (p = 0.491). Moreover, in the meta-analysis of rs1805054, drawing data from five studies, including our own (schizophrenia patients = 1366, controls = 1376), rs1805054 was also not associated with schizophrenia.
Our results indicate that tagging SNPs in HTR6 may not play a role in the pathophysiology of schizophrenia.
多项证据表明，血清素6（5-HT6）受体的基因改变可能与精神分裂症的病理生理学相关。我们试图在病例对照研究和荟萃分析中评估5-HT6受体基因改变与精神分裂症之间的关系。
我们对日本精神分裂症患者（n = 836）和对照组（n = 857）进行了5-HT6受体基因（HTR6）的关联研究。选择了五个标签单核苷酸多态性（SNP），包括HTR6中的rs1805054（C267T）。此外，我们对rs1805054（已在其他研究中进行过检测）与精神分裂症进行了荟萃分析，检索了截至2011年8月的PubMed数据库。
在简单和多元逻辑回归分析中，校正潜在混杂因素后，HTR6中的标签SNP与精神分裂症在任何基因型模型中均无显著关联。同样，在全标记单倍型多元逻辑回归分析中也未发现显著关联（p = 0.491）。此外，在rs1805054的荟萃分析中，纳入包括我们自己研究在内的五项研究的数据（精神分裂症患者 = 1366，对照组 = 1376），rs1805054也与精神分裂症无关。
我们的结果表明，HTR6中的标签SNP可能在精神分裂症的病理生理学中不起作用。
