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[小儿二尖瓣疾病的流行病学:一项黎巴嫩的研究]

[Epidemiology of mitral valve disease in pediatrics: a Lebanese study].

作者信息

Chehab Ghassan, El-Rassi Issam, Chokor Imad, Hammoud Chawke, Saliba Zakhia

机构信息

Service de pédiatrie et de chirurgie cardio-vasculaire, Centre hospitalier universitaire Hôtel-Dieu de France.

出版信息

J Med Liban. 2011 Oct-Dec;59(4):197-201.

Abstract

OBJECTIVES

To study the incidence, etiology, clinical signs and treatment of children with mitral valve disease in Lebanon.

PATIENTS AND METHODS

This is a retrospective study on a period of 9 years (between May 1, 1999 and April 30, 2008), including a group of children with congenital and acquired heart disease, consecutively enrolled in the National Register of Pediatric and Congenital Heart Disease, Lebanese Society of Cardiology.

RESULTS

2586 new patients aged 0-18 years were recorded. Among them, 128 (4.9%) had mitral disease. The causes were congenital in 65% of the cases (28% were associated with other congenital heart anomalies, especially a double outlet right ventricle) and acquired in 35% of the cases (91% were secondary to rheumatic fever). The diagnosis of the disease was fortuitous in 24% of the cases, and a murmur was discovered on auscultation in 53% of the cases. The majority of children showed mitral regurgitation (86%). The regurgitation was severe in 12% of the cases. Half of the children received medical or surgical treatment. The mortality of this disease reached 2%.

CONCLUSION

Congenital anomalies of the mitral valve are the most common cause of mitral regurgitation in children. Rheumatic disease remains another important cause of mitral disease in Lebanon. A high index of suspicion must exist, since the vast majority of diseases are found fortuitously or during simple auscultation.

摘要

目的

研究黎巴嫩二尖瓣疾病患儿的发病率、病因、临床体征及治疗方法。

患者与方法

这是一项为期9年(1999年5月1日至2008年4月30日)的回顾性研究,纳入了一组先天性和后天性心脏病患儿,这些患儿连续登记在黎巴嫩心脏病学会儿科和先天性心脏病国家登记册中。

结果

记录了2586例0至18岁的新患者。其中,128例(4.9%)患有二尖瓣疾病。病因方面,65%为先天性(28%与其他先天性心脏异常相关,尤其是右心室双出口),35%为后天性(91%继发于风湿热)。24%的病例疾病诊断为偶然发现,53%的病例通过听诊发现杂音。大多数患儿表现为二尖瓣反流(86%)。12%的病例反流严重。一半的患儿接受了药物或手术治疗。该疾病的死亡率达2%。

结论

二尖瓣先天性异常是儿童二尖瓣反流最常见的原因。在黎巴嫩,风湿性疾病仍是二尖瓣疾病的另一个重要原因。由于绝大多数疾病是偶然发现或在简单听诊时发现的,因此必须保持高度的怀疑指数。

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