Stone A B, Pearlstein T B, Brown W A
Univeristy of Massachusetts Medical School, Westfield 01085.
Psychopharmacol Bull. 1990;26(3):331-5.
Despite many associations between premenstrual syndrome (PMS) and major depression, there have been no placebo-controlled trials of an antidepressant in this disorder. We conducted a double-blind, randomized, placebo-controlled trial of fluoxetine in the treatment of severe PMS. The diagnosis of PMS was made using daily, prospective, self-rating forms over two menstrual cycles. Women who continued to meet criteria for PMS after a single-blind trial of placebo during one menstrual cycle were randomly assigned to treatment for two menstrual cycles with either fluoxetine at 20 mg/day (n = 9) or placebo (n = 6). Eight of the 9 subjects receiving fluoxetine responded to treatment, whereas only 1 of the 6 receiving placebo responded (p less than .025). All subjects on fluoxetine elected to continue with this treatment after completion of the study. These preliminary results suggest that fluoxetine is an effective and well-tolerated treatment for severe PMS.
尽管经前综合征（PMS）与重度抑郁症之间存在诸多关联，但针对该病症使用抗抑郁药的安慰剂对照试验却尚未开展。我们进行了一项关于氟西汀治疗重度经前综合征的双盲、随机、安慰剂对照试验。经前综合征的诊断是通过在两个月经周期内每日使用前瞻性自评表格来做出的。在一个月经周期进行单盲安慰剂试验后仍符合经前综合征标准的女性，被随机分配接受为期两个月经周期的治疗，其中一组每日服用20毫克氟西汀（n = 9），另一组服用安慰剂（n = 6）。接受氟西汀治疗的9名受试者中有8名对治疗有反应，而接受安慰剂治疗的6名受试者中只有1名有反应（p小于0.025）。完成研究后，所有服用氟西汀的受试者都选择继续这种治疗。这些初步结果表明，氟西汀是治疗重度经前综合征的一种有效且耐受性良好的疗法。
