Agha-Hosseini M, Kashani L, Aleyaseen A, Ghoreishi A, Rahmanpour H, Zarrinara A R, Akhondzadeh S
Infertility Center of Dr Shariati Hospital, Vali Asr Reproductive Health Research Center, Tehran University of Medical Sciences, Tehran, Iran.
BJOG. 2008 Mar;115(4):515-9. doi: 10.1111/j.1471-0528.2007.01652.x.
The aim of this double-blind and placebo-controlled trial was to investigate whether saffron (stigma of Crocus sativus L.) could relieve symptoms of premenstrual syndrome (PMS).
Double-blind, randomised and placebo-controlled trial.
Departments of Gynaecology/Obstetrics and Psychiatry, Tehran and Zanjan University of Medical Sciences.
Women aged 20-45 years with regular menstrual cycles and experience of PMS symptoms for at least 6 months were eligible for the study.
Women were randomly assigned to receive capsule saffron 30 mg/day (15 mg twice a day; morning and evening) (group A) or capsule placebo (twice a day) for a two menstrual cycles (cycles 3 and 4).
The primary outcome measure was the Daily Symptom Report, and secondary outcome measure was the Hamilton Depression Rating Scale.
In this trial, saffron was found to be effective in relieving symptoms of PMS. A significant difference was observed in efficacy of saffron in cycles 3 and 4 in the Total Premenstrual Daily Symptoms and Hamilton Depression Rating Scale.
The results of this study indicate the efficacy of C. sativus L. in the treatment of PMS. However, a tolerable adverse effects profile of saffron may well confirm the application of saffron as an alternative treatment for PMS. These results deserved further investigations.
本双盲安慰剂对照试验旨在研究藏红花（番红花柱头）是否能缓解经前综合征（PMS）症状。
双盲、随机、安慰剂对照试验。
德黑兰和赞詹医科大学妇产科及精神科。
年龄在20 - 45岁、月经周期规律且有经前综合征症状至少6个月的女性符合本研究条件。
女性被随机分配接受30毫克/天的藏红花胶囊（15毫克，早晚各一次）（A组）或安慰剂胶囊（每日两次），为期两个月经周期（第3和第4周期）。
主要观察指标为每日症状报告，次要观察指标为汉密尔顿抑郁量表。
在本试验中，发现藏红花对缓解经前综合征症状有效。在第3和第4周期，藏红花在经前每日总症状和汉密尔顿抑郁量表的疗效上存在显著差异。
本研究结果表明番红花在治疗经前综合征方面具有疗效。然而，藏红花可耐受的不良反应情况可能充分证实其作为经前综合征替代治疗方法的应用价值。这些结果值得进一步研究。
