Javaid J I, Sharma R P, Janicak P G, Davis J M
Department of Psychiatry, University of Illinois, Chicago.
Psychopharmacol Bull. 1990;26(3):361-5.
Plasma homovanillic acid (pHVA) was measured in 40 inpatients (25 schizophrenic and 15 nonschizophrenic patients) who underwent up to 3 weeks of drug washout. Schizophrenic patients were then treated with trifluoperazine for 4 weeks, and weekly behavioral and pHVA measures were obtained. The baseline pHVA had no relationship to age, sex, washout period, diagnosis, or behavioral rating scores. In schizophrenic patients, the baseline pHVA did not differ significantly from any value obtained during 4 weeks of treatment. Although there was significant improvement in clinical symptoms, this was not related to changes in pHVA. Further, changes in any of the four Brief Psychiatric Rating Scale (BPRS) factors (i.e., positive symptoms, negative symptoms, hostility/suspicion, or anxiety/depression) were not correlated with changes in pHVA. Although other studies have reported a positive correlation between pHVA and psychotic symptoms, results of this study suggest that any observed relationship between pHVA and psychosis must be carefully interpreted.
对40名住院患者（25名精神分裂症患者和15名非精神分裂症患者）进行了血浆高香草酸（pHVA）测量，这些患者经历了长达3周的药物洗脱期。然后，精神分裂症患者接受三氟拉嗪治疗4周，并每周进行行为和pHVA测量。基线pHVA与年龄、性别、洗脱期、诊断或行为评分无关。在精神分裂症患者中，基线pHVA与治疗4周期间获得的任何值均无显著差异。虽然临床症状有显著改善，但这与pHVA的变化无关。此外，四个简明精神病评定量表（BPRS）因子（即阳性症状、阴性症状、敌意/怀疑或焦虑/抑郁）中的任何一个的变化均与pHVA的变化无关。尽管其他研究报告了pHVA与精神病症状之间存在正相关，但本研究结果表明，必须谨慎解释观察到的pHVA与精神病之间的任何关系。
