Janicak P G, Javaid J I, Sharma R P, Comaty J E, Peterson J, Davis J M
Illinois State Psychiatric Institute, Chicago 60612.
J Clin Psychopharmacol. 1989 Oct;9(5):340-6.
The authors studied 36 acutely psychotic inpatients who were diagnosed as having either a schizophrenic (N = 30) or other psychotic (N = 6) disorder. After a washout phase averaging 18 days, all patients were placed on trifluoperazine 5 mg orally twice a day. Plasma levels of trifluoperazine were obtained on days 11 and 15 of treatment and then compared with clinical response. After 2 weeks of treatment an inverted U-shaped relationship was found between change scores on the Brief Psychiatric Rating Scale and trifluoperazine plasma levels.
作者研究了36名急性精神病住院患者，这些患者被诊断为患有精神分裂症（N = 30）或其他精神病性障碍（N = 6）。在平均为期18天的洗脱期后，所有患者开始口服三氟拉嗪，每天两次，每次5毫克。在治疗的第11天和第15天测定三氟拉嗪的血浆水平，然后将其与临床反应进行比较。治疗2周后，发现简明精神病评定量表的变化分数与三氟拉嗪血浆水平之间呈倒U形关系。
