Soler C, Núñez J, Pertusa J F, Núñez M, Núñez A
Departament de Biologia Animal, Secció de Fisiologia, Facultat de Biològiques, Universitat de València, Spain.
Rev Esp Fisiol. 1990 Jun;46(2):147-53.
Adult Wistar rats were either partial (caput) and bilaterally epididymectomized or bilaterally efferentectomized, as controls of duct obstruction. The effects on testicular germinal epithelium were studied at 7, 9, 11, 13, 15, 17, 19, 21, 23 and 25 days after surgery. No abnormalities were detected in sham-operated animals. Epididymectomized animals showed different levels of alterations with progressive disruption of the seminiferous epithelium, emergence of multinucleated bodies and some tubules obliterated by degenerated cells and cellular debris. Half way through the experiment there were tubules lacking their epithelia, as well as the Sertoli cells. On the 25th day degeneration was so important that is affected not only the epithelium (missing in almost all tubules) but also the tubular morphology. Eventually efferentectomized animals showed a progressive alteration, but its level was much lower than that observed after partial epididymectomy, indicating a possible specific function of the caput epididymidis in the control of testicular function.
成年Wistar大鼠进行部分（头部）双侧附睾切除术或双侧输出小管切除术，作为管道阻塞的对照。在术后7、9、11、13、15、17、19、21、23和25天研究对睾丸生精上皮的影响。假手术动物未检测到异常。附睾切除的动物表现出不同程度的改变，生精上皮逐渐破坏，出现多核体，一些小管被退化细胞和细胞碎片阻塞。实验进行到一半时，有些小管缺乏上皮以及支持细胞。在第25天，退化非常严重，不仅影响上皮（几乎所有小管中都缺失），还影响小管形态。最终，输出小管切除的动物也出现了逐渐的改变，但其程度远低于部分附睾切除后观察到的程度，表明附睾头部在睾丸功能控制中可能具有特定功能。
